WEKO3
アイテム
{"_buckets": {"deposit": "b4d206e2-8a30-401b-bd9e-2a429cf1859a"}, "_deposit": {"created_by": 2, "id": "1666", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "1666"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00001666", "sets": ["159"]}, "author_link": ["8027", "8023", "8025", "8029", "8031", "8030", "8026", "8024", "8028"], "item_3_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "93", "bibliographicPageStart": "87", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "Acta medica Nagasakiensia"}]}]}, "item_3_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Serum alkaline phosphatase (ALP) could be an indicator of osteoblastic activity, which initiates hematopoietic stem cell (CD34-positive cell) production in bone marrow. Since chronic inflammation, which is a known risk factor for hypertension and endothelium \ndysfunction, stimulates bone marrow activity, ALP could be positively associated with hypertension. To clarify those associations, we conducted a cross-sectional study of 479 elderly Japanese men aged 60-69. Circulating CD34-positive cell levels could influence associations between serum ALP and hypertension because CD34-positive cell production is also a factor known to \ncontribute to endothelial repair. Therefore, participants were stratified by the median value of circulating CD34-positive cell levels (1.00 cells/μL). A low level of circulating CD34-positive cells was identified in 240 members of the study population. A significantly \npositive association of ALP with hypertension was detected among participants with low circulating CD34-positive cell levels (multivariable-OR (odds ratio) for hypertension resulting from a 1 standard deviation (SD) increment in serum ALP (58.3 IU/L) = 1.44 (1.06, 1.95)) but not among those with high CD34-positive cell levels (multivariable-OR=0.91 (0.67, 1.23)). We also observed a significant effect of the interaction of circulating CD34-positive cell levels on the association between serum ALP and hypertension (multivariable p=0.011). Serum ALP was found to be positively associated with hypertension among elderly participants with low but not with high circulating CD34-positive cell levels. Since CD34-positive cells are a factor known to contribute to endothelial repair, capability for endothelial repair can be expected to have an effect on the association between serum ALP and hypertension.", "subitem_description_type": "Abstract"}]}, "item_3_description_64": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Acta medica Nagasakiensia, 62(3), pp.87-93; 2019", "subitem_description_type": "Other"}]}, "item_3_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagasaki University School of Medicine"}]}, "item_3_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508430", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00016055", "subitem_source_identifier_type": "ISSN"}]}, "item_3_text_62": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "02"}]}, "item_3_text_63": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "長崎大学医学部"}]}, "item_3_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsubara, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "8023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamanashi, Hirotomo"}], "nameIdentifiers": [{"nameIdentifier": "8024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagaura, Yuki"}], "nameIdentifiers": [{"nameIdentifier": "8025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyoura, Kairi"}], "nameIdentifiers": [{"nameIdentifier": "8026", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoda, Aya"}], "nameIdentifiers": [{"nameIdentifier": "8027", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "8028", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamichi, Seiko"}], "nameIdentifiers": [{"nameIdentifier": "8029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maeda, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "8030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimizu, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "8031", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ActMed62_87.pdf", "filesize": [{"value": "493.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 493000.0, "url": {"label": "ActMed62_87.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/1666/files/ActMed62_87.pdf"}, "version_id": "3a30817a-954e-4d81-a55f-8b9a7be914e7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ALP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hypertension", "subitem_subject_scheme": "Other"}, {"subitem_subject": "elderlymen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Japanese", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD34", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men"}]}, "item_type_id": "3", "owner": "2", "path": ["159"], "permalink_uri": "http://hdl.handle.net/10069/38941", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-05"}, "publish_date": "2019-04-05", "publish_status": "0", "recid": "1666", "relation": {}, "relation_version_is_last": true, "title": ["Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men"], "weko_shared_id": 2}
Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men
http://hdl.handle.net/10069/38941
http://hdl.handle.net/10069/38941dc5dc590-caa3-4233-8726-838415f03c09
名前 / ファイル | ライセンス | アクション |
---|---|---|
ActMed62_87.pdf (493.0 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-04-05 | |||||
タイトル | ||||||
タイトル | Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ALP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | elderlymen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD34 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Matsubara, Hiroshi
× Matsubara, Hiroshi× Yamanashi, Hirotomo× Nagaura, Yuki× Kiyoura, Kairi× Yoda, Aya× Kondo, Hideaki× Nakamichi, Seiko× Maeda, Takahiro× Shimizu, Yuji |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Serum alkaline phosphatase (ALP) could be an indicator of osteoblastic activity, which initiates hematopoietic stem cell (CD34-positive cell) production in bone marrow. Since chronic inflammation, which is a known risk factor for hypertension and endothelium dysfunction, stimulates bone marrow activity, ALP could be positively associated with hypertension. To clarify those associations, we conducted a cross-sectional study of 479 elderly Japanese men aged 60-69. Circulating CD34-positive cell levels could influence associations between serum ALP and hypertension because CD34-positive cell production is also a factor known to contribute to endothelial repair. Therefore, participants were stratified by the median value of circulating CD34-positive cell levels (1.00 cells/μL). A low level of circulating CD34-positive cells was identified in 240 members of the study population. A significantly positive association of ALP with hypertension was detected among participants with low circulating CD34-positive cell levels (multivariable-OR (odds ratio) for hypertension resulting from a 1 standard deviation (SD) increment in serum ALP (58.3 IU/L) = 1.44 (1.06, 1.95)) but not among those with high CD34-positive cell levels (multivariable-OR=0.91 (0.67, 1.23)). We also observed a significant effect of the interaction of circulating CD34-positive cell levels on the association between serum ALP and hypertension (multivariable p=0.011). Serum ALP was found to be positively associated with hypertension among elderly participants with low but not with high circulating CD34-positive cell levels. Since CD34-positive cells are a factor known to contribute to endothelial repair, capability for endothelial repair can be expected to have an effect on the association between serum ALP and hypertension. |
|||||
書誌情報 |
Acta medica Nagasakiensia 巻 62, 号 3, p. 87-93, 発行日 2019-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
02 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 62(3), pp.87-93; 2019 |