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We measured the serum copper levels of bed-ridden patients receiving enteral feeding, and evaluated optical and ultrastructural features of bone marrow before and after copper supplementation.Patients and Methods Serum samples were obtained from 15 bed-ridden elderly patients receiving tube feeding (TF) and 10 age-matched bed-ridden patients who took food orally (CO), and the copper ceruloplasmin concentration of each sample was measured. Bone marrow samples were obtained from patients who exhibited copper deficiency and leukopenia and/or anemia before and after the copper supplementation, for use in light and electron microscopic analysis.Results The tube-fed patients had significantly lower mean serum copper and ceruloplasmin concentrations than the control patients. Seven of the 15 tube-fed patients had reduced serum copper concentrations and leukopenia. Six of those 7 patients also had anemia. Copper sulfate was administered to those 7 patients by enteral tube;their copper concentration, anemia and leukopenia improved within 1 month after they were administered copper sulfate. In the bone marrow examination before copper supplementation, light microscopy showed cytoplasmic vacuolization in both myeloid and erythroid precursors, and electron microscopy showed electron-dense deposits in mitochondria and cytoplasm of erythroid and myeloid cells. After copper supplementation, these pathological changes disappeared.Conclusions Bicytopenia is likely to occur in tube-fed patients with copper deficiency. Copper deficiency appears to be associated with cytoplasmic vacuolization and electron-dense deposits in mitochondria in erythroid and myeloid cells.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Internal Medicine, vol.46(12), pp.839-844; 2007", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本内科学会"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2169/internalmedicine.46.6264", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (c) 2007 (社)日本内科学会"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09182918", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "The Japanese Society of Internal Medicine"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Chen, Chun_Chuan"}], "nameIdentifiers": [{"nameIdentifier": "64164", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshima, Fuminao"}], "nameIdentifiers": [{"nameIdentifier": "64165", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Takashige"}], "nameIdentifiers": [{"nameIdentifier": "64166", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Murase, Kunihiko"}], "nameIdentifiers": [{"nameIdentifier": "64167", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohtani, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "64168", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Isomoto, Hajime"}], "nameIdentifiers": [{"nameIdentifier": "64169", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shikuwa, Saburo"}], "nameIdentifiers": [{"nameIdentifier": "64170", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Omagari, Katsuhisa"}], "nameIdentifiers": [{"nameIdentifier": "64171", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuta, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "64172", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozono, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "64173", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "64174", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "IM_46_12_839.pdf", "filesize": [{"value": "943.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 943200.0, "url": {"label": "IM_46_12_839.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16687/files/IM_46_12_839.pdf"}, "version_id": "e03bc0a9-a0b4-40b6-b145-d2c927a5a082"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "copper deficiency", "subitem_subject_scheme": "Other"}, {"subitem_subject": "electron microscopy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tube feeding", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinicopathological Analysis of Hematological Disorders in Tube-Fed Patients with Copper Deficiency", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinicopathological Analysis of Hematological Disorders in Tube-Fed Patients with Copper Deficiency"}]}, "item_type_id": "2", "owner": "2", "path": ["30"], "permalink_uri": "http://hdl.handle.net/10069/22570", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-12-04"}, "publish_date": "2009-12-04", "publish_status": "0", "recid": "16687", "relation": {}, "relation_version_is_last": true, "title": ["Clinicopathological Analysis of Hematological Disorders in Tube-Fed Patients with Copper Deficiency"], "weko_shared_id": 2}
Clinicopathological Analysis of Hematological Disorders in Tube-Fed Patients with Copper Deficiency
http://hdl.handle.net/10069/22570
http://hdl.handle.net/10069/22570259a6a0f-f416-417f-ba0a-618bc2a04552
名前 / ファイル | ライセンス | アクション |
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IM_46_12_839.pdf (943.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-04 | |||||
タイトル | ||||||
タイトル | Clinicopathological Analysis of Hematological Disorders in Tube-Fed Patients with Copper Deficiency | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | copper deficiency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | electron microscopy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tube feeding | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chen, Chun_Chuan
× Chen, Chun_Chuan× Takeshima, Fuminao× Miyazaki, Takashige× Murase, Kunihiko× Ohtani, Hiroshi× Isomoto, Hajime× Shikuwa, Saburo× Omagari, Katsuhisa× Mizuta, Yohei× Ozono, Yoshiyuki× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Object Anemia and leukopenia caused by copper deficiency are well-documented consequences of long-term total parenteral nutrition. We measured the serum copper levels of bed-ridden patients receiving enteral feeding, and evaluated optical and ultrastructural features of bone marrow before and after copper supplementation.Patients and Methods Serum samples were obtained from 15 bed-ridden elderly patients receiving tube feeding (TF) and 10 age-matched bed-ridden patients who took food orally (CO), and the copper ceruloplasmin concentration of each sample was measured. Bone marrow samples were obtained from patients who exhibited copper deficiency and leukopenia and/or anemia before and after the copper supplementation, for use in light and electron microscopic analysis.Results The tube-fed patients had significantly lower mean serum copper and ceruloplasmin concentrations than the control patients. Seven of the 15 tube-fed patients had reduced serum copper concentrations and leukopenia. Six of those 7 patients also had anemia. Copper sulfate was administered to those 7 patients by enteral tube;their copper concentration, anemia and leukopenia improved within 1 month after they were administered copper sulfate. In the bone marrow examination before copper supplementation, light microscopy showed cytoplasmic vacuolization in both myeloid and erythroid precursors, and electron microscopy showed electron-dense deposits in mitochondria and cytoplasm of erythroid and myeloid cells. After copper supplementation, these pathological changes disappeared.Conclusions Bicytopenia is likely to occur in tube-fed patients with copper deficiency. Copper deficiency appears to be associated with cytoplasmic vacuolization and electron-dense deposits in mitochondria in erythroid and myeloid cells. | |||||
書誌情報 |
Internal Medicine 巻 46, 号 12, p. 839-844, 発行日 2007-06 |
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出版者 | ||||||
出版者 | 日本内科学会 | |||||
出版者別言語 | ||||||
The Japanese Society of Internal Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09182918 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2169/internalmedicine.46.6264 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2007 (社)日本内科学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Internal Medicine, vol.46(12), pp.839-844; 2007 |