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Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac.
http://hdl.handle.net/10069/22640
http://hdl.handle.net/10069/22640c1aeaf11-e206-4b94-a963-4f7e6bcdd56a
名前 / ファイル | ライセンス | アクション |
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ABC391_1057.pdf (180.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-15 | |||||
タイトル | ||||||
タイトル | Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diclofenac | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microdialysate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pharmacokinetic interaction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wada, Mitsuhiro
× Wada, Mitsuhiro× Yokota, Chiaki× Ogata, Yasuhiro× Kuroda, Naotaka× Yamada, Hideyuki× Nakashima, Kenichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A sensitive high-performance liquid chromatography (HPLC)-fluorescence method for determination of morphine (Mor) in rat brain and blood microdialysates was developed using 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) as a label. Mor was labeled with DIB-Cl under mild reaction conditions (at room temperature for 10 min). The separation of DIB-Mor was carried out on an octadecylsilica (ODS) column with CH(3)CN/0.1 M acetate buffer (pH 5.4) within 14 min. The detection limits of Mor in brain and blood microdialysates at a signal-to-noise ratio of 3 were 0.4 and 0.6 ng mL(-1), respectively. The proposed method was successfully applied to the preliminarily study of potential pharmacokinetic interaction between Mor and diclofenac. | |||||
書誌情報 |
Analytical and bioanalytical chemistry 巻 391, 号 3, p. 1057-1062, 発行日 2008-06 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16182642 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1618-2650 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11610734 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18418582 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00216-008-2070-4 | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2008 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Analytical and bioanalytical chemistry, 391(3), pp.1057-1062; 2008 |