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Bactericidal Activity in Filtrated Supernatant of Streptococcus Sanguinis against Multidrug-Resistant Pseudomonas Aeruginosa
http://hdl.handle.net/10069/22645
http://hdl.handle.net/10069/2264546e66304-21d4-4622-871e-50e2801e73ce
名前 / ファイル | ライセンス | アクション |
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TJEM219_79.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-15 | |||||
タイトル | ||||||
タイトル | Bactericidal Activity in Filtrated Supernatant of Streptococcus Sanguinis against Multidrug-Resistant Pseudomonas Aeruginosa | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acinetobacter baumannii | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bactericidal effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Multidrug-resistant Pseudomonas aeruginosa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pseudomonas aeruginosa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Streptococcus sanguinis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Watanabe, Kiwao
× Watanabe, Kiwao× Senba, Masachika× Ichinose, Akitoyo× Yamamoto, Takeshi× Ariyoshi, Koya× Matsumoto, Keizo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the past decade, multidrug-resistant Pseudomonas aeruginosa (MDRP) infection has become a serious clinical problem, due to the limitation of drug choices to fight against the bacteria. Here we explored the bactericidal activity in the filtrated supernatant of Streptococcus (S.) sanguinis against Pseudomonas (P.) aeruginosa. S. sanguinis is one of the α-hemolytic streptococci that commonly reside in the human oral cavity. A strain of S. sanguinis, isolated from the sputum of a pulmonary-disease patient, was cultured for overnight. The filtered supernatant was tested for bactericidal effect using the minimum bactericidal concentration method on 20 strains of P. aeruginosa, including two MDRP and five mucoid-type strains. The viable number of P. aeruginosa was decreased with time after exposing to the filtrated supernatant of S. sanguinis, and collapsed bacteria were detected with electron microscopy. Of the 20 strains, 19 (95%) strains of P. aeruginosa were affected by bactericidal effect. Among other species of bacteria examined, the filtrated supernatant of S. sanguinis showed remarkable bactericidal effect on 49% of indole-positive Proteus species (4/9 strains) and 60% of Acinetobacter (A.) baumannii (6/10 strains). We next investigated the property of bactericidal activity in filtrated supernatant by treating with proteinase K or autoclave. There was no change in the bactericidal activity of the filtrated supernatant after each treatment, excluding the involvement of protein and plasmid. Here, we identify the bactericidal activity in the filtrated supernatant of S. sanguinis against MDRP. This unexpected observation may contribute to the development of a novel therapeutic drug against P. aeruginosa. | |||||
書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 219, 号 2, p. 79-84, 発行日 2009-10 |
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出版者 | ||||||
出版者 | Tohoku University Medical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00408727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-3329 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863920 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1620/tjem.219.79 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2009 Tohoku University Medical Press | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Tohoku Journal of Experimental Medicine, 219(2), pp.79-84; 2009 |