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Apoptosis related mediators,among others, are known to correlate with severe dengue (SD) although no predictive validity is established. The objective of this study was to investigate the association of plasma cell-free DNA (cfDNA) with SD, and evaluate its prognostic value in SD prediction at acute phase. Methods: This was a hospital-based prospective cohort study conducted in Vietnam.All the recruited patients were required to be admitted to the hospital and were strictly monitored for various laboratory and clinical parameters(including progression to SD) until discharged. Plasma samples collected during acute phase (6-48 h before defervescence) were used to estimate the level of cfDNA. Results: Of the 61 dengue patients,SD patients (n = 8)developed shock syndrome in 4.8 days (95% CI 3.7-5.4) after the fever onset. Plasma cfDNA levels\n before the defervescence of SD patients were significantly higher than the non-SD group (p = 0.0493). 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Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue
http://hdl.handle.net/10069/38955
http://hdl.handle.net/10069/389555e8aebbf-f0a6-4ab7-8fbf-4bd410df3140
名前 / ファイル | ライセンス | アクション |
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ACMA18_10.pdf (826.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-04-10 | |||||
タイトル | ||||||
タイトル | Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell-free DNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dengue severity predictor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognostic biomarker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Severe dengue | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Phuong, Nguyen Thi Ngoc
× Phuong, Nguyen Thi Ngoc× Manh, Dao Huy× Dumre, Shyam Prakash× Mizukami, Shusaku× Weiss, Lan Nguyen× Van, Thuong Nguyen× Ha, Tran Thi Ngoc× Phuc, Le Hong× Van, An Tran× Tieu, Thuan Minh× Kamel, Mohamed Gomaa× Morra, Mostafa Ebraheem× Huong, Vu Thi Que× Huy, Nguyen Tien× Hirayama, Kenji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Considerable progress has been made in dengue management, however the lack of appropriate predictors of severity has led to huge number of unwanted admissions mostly decided on the grounds of warning signs. Apoptosis related mediators,among others, are known to correlate with severe dengue (SD) although no predictive validity is established. The objective of this study was to investigate the association of plasma cell-free DNA (cfDNA) with SD, and evaluate its prognostic value in SD prediction at acute phase. Methods: This was a hospital-based prospective cohort study conducted in Vietnam.All the recruited patients were required to be admitted to the hospital and were strictly monitored for various laboratory and clinical parameters(including progression to SD) until discharged. Plasma samples collected during acute phase (6-48 h before defervescence) were used to estimate the level of cfDNA. Results: Of the 61 dengue patients,SD patients (n = 8)developed shock syndrome in 4.8 days (95% CI 3.7-5.4) after the fever onset. Plasma cfDNA levels before the defervescence of SD patients were significantly higher than the non-SD group (p = 0.0493). From the receiver operating characteristic (ROC) curve analysis, a cut-off of > 36.9 ng/mL was able to predict SD with a good sensitivity (87.5%), specificity (54.7%), and area under the curve (AUC) (0.72, 95% CI 0.55-0.88; p = 0.0493).Conclusions: Taken together, these findings suggest that cfDNA could serve as a potential prognostic biomarker of SD. Studies with cfDNA kinetics and its combination with other biomarkers and clinical parameters would further improve the diagnostic ability for SD. |
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書誌情報 |
Annals of Clinical Microbiology and Antimicrobials 巻 18, 号 1, p. 10, 発行日 2019-03-13 |
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出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14760711 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s12941-019-0309-x | |||||
権利 | ||||||
権利情報 | c The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creat iveco mmons .org/licen ses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Annals of Clinical Microbiology and Antimicrobials, 18(1), art.no.10; 2019 |