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Regulation of bone development and extracellular matrix protein genes by RUNX2.
http://hdl.handle.net/10069/22708
http://hdl.handle.net/10069/22708a6d228c2-0fa3-40dc-802e-b1fe6769b6ef
名前 / ファイル | ライセンス | アクション |
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CTR339_189.pdf (105.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-01-18 | |||||
タイトル | ||||||
タイトル | Regulation of bone development and extracellular matrix protein genes by RUNX2. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BGLAP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | COL1A1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Extracellular matrix | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IBSP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RUNX2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Skeletal development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SPP1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Komori, Toshihisa
× Komori, Toshihisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | RUNX2 is a multifunctional transcription factor that controls skeletal development by regulating the differentiation of chondrocytes and osteoblasts and the expression of many extracellular matrix protein genes during chondrocyte and osteoblast differentiation. This transcription factor plays a major role at the late stage of chondrocyte differentiation: it is required for chondrocyte maturation and regulates Col10a1 expression in hypertrophic chondrocytes and the expression of Spp1, Ibsp, and Mmp13 in terminal hypertrophic chondrocytes. It is essential for the commitment of pluripotent mesenchymal cells to the osteoblast lineage. During osteoblast differentiation, RUNX2 upregulates the expression of bone matrix protein genes including Col1a1, Spp1, Ibsp, Bglap, and Fn1 in vitro and activates many promoters including those of Col1a1, Col1a2, Spp1, Bglap, and Mmp13. However, overexpression of Runx2 inhibits osteoblast maturation and reduces Col1a1 and Bglap expression. The inhibition of RUNX2 in mature osteoblasts does not reduce the expression of Col1a1 and Bglap in mice. Thus, RUNX2 directs pluripotent mesenchymal cells to the osteoblast lineage, triggers the expression of major bone matrix protein genes, and keeps the osteoblasts in an immature stage, but does not play a major role in the maintenance of the expression of Col1a1 or Bglap in mature osteoblasts. During bone development, RUNX2 induces osteoblast differentiation and increases the number of immature osteoblasts, which form immature bone, whereas Runx2 expression has to be downregulated for differentiation into mature osteoblasts, which form mature bone. During dentinogenesis, Runx2 expression is downregulated, and RUNX2 inhibits the terminal differentiation of odontoblasts. | |||||
書誌情報 |
Cell and tissue research 巻 339, 号 1, p. 189-195, 発行日 2010-01 |
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出版者 | ||||||
出版者 | Springer Berlin | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0302766X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1432-0878 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00600105 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19649655 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s00441-009-0832-8 | |||||
権利 | ||||||
権利情報 | c Springer-Verlag 2009 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cell and tissue research, 339(1), pp.189-195; 2010 |