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Diverse Effects of FK506 on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver.
http://hdl.handle.net/10069/22758
http://hdl.handle.net/10069/22758e4f72d7b-68ba-4fe5-8ef7-4f041627d26d
名前 / ファイル | ライセンス | アクション |
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JSR167_131.pdf (7.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-01-25 | |||||
タイトル | ||||||
タイトル | Diverse Effects of FK506 on the Apoptosis of Hepatocytes and Infiltrating Lymphocytes in an Allografted Rat Liver. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bcl-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fas | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fas ligand | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FK506 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver transplantation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Moriuchi, Hiroki
× Moriuchi, Hiroki× Kamohara, Yukio× Eguchi, Susumu× Gu, Weili× Fujioka, Hikaru× Yamamoto, Takao× Tajima, Yoshitsugu× Kanematsu, Takashi× Koji, Takehiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: The current study investigated whether FK506 (FK) regulates the apoptotic systems in allografted rat liver and the contribution of Fas/Fas-ligand system and Bcl-2 family during acute rejection. MATERIALS AND METHODS: The recipients were divided into three groups, the allo, the allo-FK, and the syn group. Rats were euthanized 1, 3, 5, and 7 d after OLT. Apoptotic activity was explored using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The expression of Fas/Fas-ligand and Bcl-2/Bax in the grafted livers was investigated by Western blotting and immunohistochemistry. RESULTS: The apoptotic index (AI) of hepatocytes in the allo-FK group was less than that in the allo group. Fas in the allo group was more intense than that in the allo-FK group in the periportal areas on day 1 and 3, while Bcl-2 in the allo group was less intense than that in the allo-FK group in the pericaval areas at all time-points after OLT. CONCLUSION: FK provides beneficial antiapoptotic effects on hepatocytes in the grafted rat livers through both the down-regulation of Fas expression in the periportal areas and the up-regulation of Bcl-2 expression in the pericaval areas. | |||||
書誌情報 |
The Journal of surgical research 巻 167, 号 1, p. 131-139, 発行日 2011-05-01 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00224804 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1095-8673 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00708021 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20018304 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jss.2009.06.054 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of surgical research, 167(1), pp.131-139; 2011 |