WEKO3
アイテム
{"_buckets": {"deposit": "eb3b5b77-7602-4284-b32f-e25ab2c4fbdf"}, "_deposit": {"created_by": 2, "id": "16885", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "16885"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00016885", "sets": ["36"]}, "author_link": ["65566", "65576", "65572", "65577", "65567", "65568", "65575", "65570", "65574", "65579", "65569", "65578", "65573", "65571"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageStart": "e304", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "PLoS Neglected Tropical Diseases"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "BACKGROUND: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS. METHODOLOGY/PRINCIPAL FINDINGS: To identify HLA alleles controlling T cell immunity against dengue virus (DV), we performed a hospital-based case control study at Children\u0027s Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 418 patients with DHF and DSS, respectively, diagnosed according to the World Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 from VL) of the same Kinh ethnicity were also analyzed as population background. In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study. The frequency of A*24 with histidine at codon 70 (A*2402/03/10), based on main anchor binding site specificity analysis in DSS and DHF patients, was significantly higher than that in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P = 0.02). CONCLUSION: This study improves our understanding of the risk of HLA-class I for severe outcome of DV infection in the light of peptide anchor binding site and provides novel evidence that HLA-class II may control disease severity (DHF to DSS) in DV infection.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "PLoS Neglected Tropical Diseases, 2(10), e304; 2008", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Public Library of Science"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "18827882", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1371/journal.pntd.0000304", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c 2008 Lan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits \nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "19352727", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1935-2735", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nguyen, Thi Phuong Lan"}], "nameIdentifiers": [{"nameIdentifier": "65566", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Mihoko"}], "nameIdentifiers": [{"nameIdentifier": "65567", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vu, Thi Que Huong"}], "nameIdentifiers": [{"nameIdentifier": "65568", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Do, Quang Ha"}], "nameIdentifiers": [{"nameIdentifier": "65569", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tran, Thi Thuy"}], "nameIdentifiers": [{"nameIdentifier": "65570", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vo, Dinh Tham"}], "nameIdentifiers": [{"nameIdentifier": "65571", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ha, Manh Tuan"}], "nameIdentifiers": [{"nameIdentifier": "65572", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Vo, Van Tuong"}], "nameIdentifiers": [{"nameIdentifier": "65573", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cao, Thi Phi Nga"}], "nameIdentifiers": [{"nameIdentifier": "65574", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tran, Van Dat"}], "nameIdentifiers": [{"nameIdentifier": "65575", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oyama, Toshifumi"}], "nameIdentifiers": [{"nameIdentifier": "65576", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Kouichi"}], "nameIdentifiers": [{"nameIdentifier": "65577", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasunami, Michio"}], "nameIdentifiers": [{"nameIdentifier": "65578", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "65579", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PLoSNeg2_304.pdf", "filesize": [{"value": "136.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 136600.0, "url": {"label": "PLoSNeg2_304.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/16885/files/PLoSNeg2_304.pdf"}, "version_id": "e2a424ee-f80f-4b3d-a217-035740a97402"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome."}]}, "item_type_id": "2", "owner": "2", "path": ["36"], "permalink_uri": "http://hdl.handle.net/10069/22766", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-01-27"}, "publish_date": "2010-01-27", "publish_status": "0", "recid": "16885", "relation": {}, "relation_version_is_last": true, "title": ["Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome."], "weko_shared_id": -1}
Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome.
http://hdl.handle.net/10069/22766
http://hdl.handle.net/10069/227663d8b9a36-a73b-4e1e-9222-2f786585f071
名前 / ファイル | ライセンス | アクション |
---|---|---|
PLoSNeg2_304.pdf (136.6 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-01-27 | |||||
タイトル | ||||||
タイトル | Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nguyen, Thi Phuong Lan
× Nguyen, Thi Phuong Lan× Kikuchi, Mihoko× Vu, Thi Que Huong× Do, Quang Ha× Tran, Thi Thuy× Vo, Dinh Tham× Ha, Manh Tuan× Vo, Van Tuong× Cao, Thi Phi Nga× Tran, Van Dat× Oyama, Toshifumi× Morita, Kouichi× Yasunami, Michio× Hirayama, Kenji |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS. METHODOLOGY/PRINCIPAL FINDINGS: To identify HLA alleles controlling T cell immunity against dengue virus (DV), we performed a hospital-based case control study at Children's Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 418 patients with DHF and DSS, respectively, diagnosed according to the World Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 from VL) of the same Kinh ethnicity were also analyzed as population background. In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study. The frequency of A*24 with histidine at codon 70 (A*2402/03/10), based on main anchor binding site specificity analysis in DSS and DHF patients, was significantly higher than that in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P = 0.02). CONCLUSION: This study improves our understanding of the risk of HLA-class I for severe outcome of DV infection in the light of peptide anchor binding site and provides novel evidence that HLA-class II may control disease severity (DHF to DSS) in DV infection. | |||||
書誌情報 |
PLoS Neglected Tropical Diseases 巻 2, 号 10, p. e304, 発行日 2008-07 |
|||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19352727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1935-2735 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18827882 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pntd.0000304 | |||||
権利 | ||||||
権利情報 | c 2008 Lan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
|||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS Neglected Tropical Diseases, 2(10), e304; 2008 |