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Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice.
http://hdl.handle.net/10069/22768
http://hdl.handle.net/10069/227684869c96a-aa14-40d5-b3ec-3bf6a9bbcee2
名前 / ファイル | ライセンス | アクション |
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BBRC367_719.pdf (537.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-01-28 | |||||
タイトル | ||||||
タイトル | Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD4+ T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Insulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Insulitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-obese diabetic mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peptide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyinosinic-polycytidylic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Regulatory T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type 1 diabetes | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fukushima, Keiko
× Fukushima, Keiko× Abiru, Norio× Nagayama, Yuji× Kobayashi, Masakazu× Satoh, Tsuyoshi× Nakahara, Mami× Kawasaki, Eiji× Yamasaki, Hironori× Ueha, Satoshi× Matsushima, Koji× Liu, Edwin× Eguchi, Katsumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Insulin peptide B:9-23 is a major autoantigen in type 1 diabetes. Combined treatment with B:9-23 peptide and polyinosinic-polycytidylic acid (poly I:C), but neither alone, induce insulitis in normal BALB/c mice. In contrast, the combined treatment accelerated insulitis, but prevented diabetes in NOD mice. Our immunofluorescence study with anti-CD4/anti-Foxp3 revealed that the proportion of Foxp3 positive CD4(+)CD25(+) regulatory T cells (Tregs) was elevated in the islets of NOD mice treated with B:9-23 peptide and poly I:C, as compared to non-treated mice. Depletion of Tregs by anti-CD25 antibody hastened spontaneous development of diabetes in non-treated NOD mice, and abolished the protective effect of the combined treatment and conversely accelerated the onset of diabetes in the treated mice. These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice. | |||||
書誌情報 |
Biochemical and biophysical research communications 巻 367, 号 4, p. 719-724, 発行日 2008-03-21 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006291X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1090-2104 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18194666 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2007.12.191 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and biophysical research communications, 367(4), pp.719-724; 2008 |