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Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines
http://hdl.handle.net/10069/38965
http://hdl.handle.net/10069/389656e6f9ee6-19a0-48f2-9f99-7acfcc5bb906
名前 / ファイル | ライセンス | アクション |
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RR60_171.pdf (390.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-04-18 | |||||
タイトル | ||||||
タイトル | Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA-dependent protein kinase activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA-dependent protein kinase catalytic subunit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | predictive assay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid cancer cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ihara, Makoto
× Ihara, Makoto× Ashizawa, Kiyoto× Shichijo, Kazuko× Kudo, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The prognosis and treatment of thyroid cancer depends on the type and stage of the disease.Radiosensitivity differs among cancer cells owing to their varying capacity for repair after irradiation. Radioactive iodine can be used to destroy thyroid cancer cells. However, patient prognosis and improvement after irradiation varies. Therefore, predictive measures are important for avoiding unnecessary exposure to radiation.We describe a new method for predicting the effects of radiation in individual cases of thyroid cancer based on the DNA-dependent protein kinase (DNA-PK) activity level in cancer cells.The radiation sensitivity, DNA-PK activity, and cellular levels of DNA-PK complex subunits in five human thyroid cancer cell lines were analyzed in vitro. A positive correlation was observed between the D 10 value (radiation dose that led to 10% survival) of cells and DNA-PK activity. This correlation was not observed after treatment with NU7441, a DNA-PK-specific inhibitor. A significant correlation was also observed between DNA-PK activity and expression levels of the DNA-PK catalytic subunit (DNA-PKcs). Cells expressing low DNA-PKcs levels were radiation-sensitive, and cells expressing high DNA-PKcs levels were radiation-resistant. Our results indicate that radiosensitivity depends on the expression level of DNA-PKcs in thyroid cancer cell lines. Thus, the DNA-PKcs expression level is a potential predictive marker of the success of radiation therapy for thyroid tumors. | |||||
書誌情報 |
Journal of Radiation Research 巻 60, 号 2, p. 171-177, 発行日 2019-03 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13499157 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jrr/rry097 | |||||
権利 | ||||||
権利情報 | c The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research, 60(2), pp.171-177; 2019 |