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Localization of cortactin is associated with colorectal cancer development.
http://hdl.handle.net/10069/24542
http://hdl.handle.net/10069/245420898429a-48e5-49e4-8b1d-72bd5603239c
名前 / ファイル | ライセンス | アクション |
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IJO35_1271.pdf (6.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-01-04 | |||||
タイトル | ||||||
タイトル | Localization of cortactin is associated with colorectal cancer development. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Colon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cortactin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ZO-1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirakawa, Hiroshi
× Hirakawa, Hiroshi× Shibata, Kenichiro× Nakayama, Toshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cortactin is a ubiquitously expressed actin filament (F-actin)-binding protein that stabilizes F-actin networks and promotes actin polymerization by activating the actin-related protein 2/3 (Arp2/3) complex. Overexpression of cortactin in cancer cells stimulate cell migration, invasion, and experimental metastasis; however, the underlying mechanism in cortactin involvement in tumor progression is not fully understood. Recently, a direct interaction between zonula occludens-1 (ZO-1) and cortactin in epithelial cells was reported. The present study aimed to further clarify the significance of the interaction between cortactin and ZO-1 in cancer progression. Cortactin expression and localization in colorectal human cancer tissues were evaluated by immunohistochemistry and immunofluorescence. Co-immunoprecipitation and immunofluorescence analysis revealed cortactin and ZO-1 interaction and localization in cancer cells. In our study, the localization of cortactin is a crucial marker for lymph node metastasis in colorectal cancer. We show how the localization of cortactin effects cancer development. A molecular interaction between cortactin and ZO-1 in migrating or polarized cancer cells was revealed. This is the first report to show the interaction of cortactin and ZO-1 in colorectal cancer progression. We conclude that localization of cortactin in cancer cells and interaction between ZO-1 and cortactin are crucial for cancer progression. | |||||
書誌情報 |
International journal of oncology 巻 35, 号 6, p. 1271-1276, 発行日 2009-12 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10196439 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17912423 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10992511 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19885549 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International journal of oncology, 35(6), pp.1271-1276; 2009 |