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Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats.
http://hdl.handle.net/10069/20859
http://hdl.handle.net/10069/20859bd81632e-11b1-4715-8f29-7fe4f8a49e04
名前 / ファイル | ライセンス | アクション |
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NeuLet450_270.pdf (240.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-01-26 | |||||
タイトル | ||||||
タイトル | Effects of midazolam on acquisition and extinction of conditioned taste aversion memory in rats. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Midazolam | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CTA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Memory | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acquisition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Extinction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amnesia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Yohimbin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Noradrenergic system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishitobi, Shingo
× Ishitobi, Shingo× Ayuse, Takao× Yoshida, Harushi× Oi, Kumiko× Toda, Kazuo× Miyamoto, Takenori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Some intravenous anesthetic agents such as midazolam are known to induce anterograde and retrograde amnesia. We analyzed the effect of midazolam by the conditioned taste aversion (CTA) acquisition and retention. After the rats were offered 0.1% sodium saccharin (Sac) as conditioned stimulus (CS), an intraperitoneal (i.p.) injection of several concentrations (5-30mg/kg) of midazolam was followed by an i.p. injection of 0.15M LiCl (2% of body weight) as unconditioned stimulus (US). The rats, which acquired CTA by every CS-US paradigm, strongly avoided Sac on the 1st test day after conditioning and maintained the avoidance for 3 days. We have already reported that Sac intake abruptly increased on the 2nd test day and the almost complete extinction occurred on the 3rd test day after conditioning by injection of subhypnotic dose of propofol before LiCl-injection. In contrast, we found that subhypnotic dose of midazolam suppressed not only CTA acquisition, but also CTA retention. On the other hand, an alpha2-adrenergic blocker, yohimbin (1mg/kg) suppressed only the CTA retention. These results suggest that the subhypnotic doses of midazolam firstly affect the acquisition mechanism of the CTA memory (CTAM), resulting the suppression of the retention of CTAM. | |||||
書誌情報 |
Neuroscience letters 巻 450, 号 3, p. 270-274, 発行日 2009-02 |
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出版者 | ||||||
出版者 | Elsevier Ireland Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03043940 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00754925 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19047011 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neulet.2008.11.044 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 Elsevier Ireland Ltd All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neuroscience Letters, 450(3), pp.270-274; 2009 |