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Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells
http://hdl.handle.net/10069/20895
http://hdl.handle.net/10069/208953b5c5462-5992-43be-83fd-0f250e751cff
名前 / ファイル | ライセンス | アクション |
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110006820173.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-02-02 | |||||
タイトル | ||||||
タイトル | Protection by Polaprezinc Against Radiation-Induced Apoptosis in Rat Jejunal Crypt Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation-induced apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polaprezinc | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intestine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuu-Matsuyama, Mutsumi
× Matsuu-Matsuyama, Mutsumi× Shichiji, Kazuko× Okaichi, Kumio× Nakayama, Toshiyuki× Nakashima, Masahiro× Uemura, Takashi× Niino, Daisuke× Sekine, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Polaprezinc, an anti-ulcer drug, is a chelate compound consisting of zinc and L-carnosine. Polaprezinc has been shown to prevent gastric mucosal injury. The anti ulcer effects of polaprezinc have been ascribed to its antioxidative property. The effect of polaprezinc on ionizing radiation-induced apoptosis was studied in the jejunal epithelial crypt cells of rats. Seven-to eight week-old Wistar rats, which were treated with 100 mg/kg of polaprezinc orally 1h before irradiation or 2% carboxymethyl cellulose sodium in controls, were exposed to whole body X-ray irradiation at 2 Gy. The number of apoptotic cells per jejunum crypt was counted in haematoxylin and eosin stained sections at 0-6 h after irradiation. TUNEL positive cells and immunopositive cells for active caspase-3 per crypt were also counted. Accumulation of p53, p21^<WAF1/CIP1> and Bax expression in the jejunum after irradiation were examined by Western blot analyses. Polaprezinc treatment given prior to radiation resulted in a significant reduction in numbers of apoptotic cells, TUNEL positive cells and active caspase-3 immunopositive cells in jejunal crypt cells. Polaprezinc treatment resulted in decreases of p53 accumulation, p21^<WAF1/CIP1> and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells. | |||||
書誌情報 |
Journal of Radiation Research 巻 49, 号 4, p. 341-347, 発行日 2008-07 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
出版者別言語 | ||||||
THE JAPAN RADIATION RESEARCH SOCIETY | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1269/jrr.07114 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 by THE JAPAN RADIATION RESEARCH SOCIETY | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Radiation Research, 49(4), pp.341-347; 2008 |