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In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES)
http://hdl.handle.net/10069/21456
http://hdl.handle.net/10069/214564b64ff04-6aaf-460c-b103-5cc045246665
名前 / ファイル | ライセンス | アクション |
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KJ00005072988.pdf (432.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-04-06 | |||||
タイトル | ||||||
タイトル | In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caenorhabditis elegans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metabolite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bisphenol A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bioconcentration factor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kohra, Shinya
× Kohra, Shinya× Inoue, Daisuke× Yamaguchi, Akemi× Takao, Yuji× Tominaga, Nobuaki× Arizono, Koji× Ueda, Kazuo |
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その他のタイトル | ||||||
その他のタイトル | In Vivo Evaluation of 4-Methyl-2, 4-bis(4-hydroxyphenyl) pent-1-ene (MBP), a Bisphenol A Metabolite, Using the Nematode Caenorhabditis elegans(SPECIAL ISSUE CELEBRATING TEN YEARS OF ESTABLISHMENT OF FACULTY OF ENVIRONMENTAL STUDIES) | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we investigated the lethal and sublethal effects of 4-methyl-2 ,4-bis(4-hydroxyphenyl)-pent-l-ene (MBP), a bisphenol A (BPA) metabolite, using the nematode Caenorhabditis eleganas (C. elegans) grown on Nematode Growth Medium (NGM) 1.7% agar plates. The bioconcentration factor (BCF) was also determined. The 24 hr-median lethal concentration (24 hr-LC_<50>) value of MBP was 0.49 mM (134 mg/1), and the acute toxicity of MBP against C. elegans was slightly stronger than that of BPA. In contrast to BPA, the sublethal toxicity of MBP in a multi-generation test, as determined by reproduction and fecundity, was slightly lower. The growth of animals, as determined by body lenth, was enhanced by 3-8% at 0.1 mM MBP, after 48-72 hr. The BCF value after exposure for 48 hr was determined to be approximately 19-105 as compared with the nominal concentration. | |||||
書誌情報 |
長崎大学総合環境研究 巻 環境科学部創立10周年記念特別号, p. 1-6, 発行日 2007-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446258 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11358045 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学総合環境研究. 2007, 環境科学部創立10周年記念特別号, p. 1-6 |