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The estimated tumor volume (TV) in 57 patients (22 stage Ib, 18 stage IIa, and 17 stage IIb) had radical hysterectomy was calculated on the assumption that the tumor mass was spheroid. The micro-vessel density (MVD) was evaluated as the ratio of endothelial area immunoreactive to factor-VIII related antigen (von Willebrand factor) to whole image area measured by computer-aided image analysis system. Tumor volume ranged from 0.1 to 41.0 cm3 (median 3.6 cm3) and MVD from 0.33 to 2.95 % (median 0.85 %). A significantly larger median TV was noted in women with positive pelvic node metastasis (6.3 vs 2.6 cm3, P=0.0228), parametrial invasion (8.9 vs 0.8 cm3, P\u003c 0.0001), and postoperative irradiation (5.4 vs 0.6 cm3, P=0.0007). In contrast, these clinical parameters had no effect on MVD. There was no correlation between TV and MVD. 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Prognostic Significance of Tumor Volume and Microvessel Density in Squamous Cell Carcinoma of Uterine Cervix
http://hdl.handle.net/10069/21631
http://hdl.handle.net/10069/21631d84dbc48-d41d-4fe0-84cf-16db36feb829
名前 / ファイル | ライセンス | アクション |
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acta_53_4_77.pdf (373.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-04-22 | |||||
タイトル | ||||||
タイトル | Prognostic Significance of Tumor Volume and Microvessel Density in Squamous Cell Carcinoma of Uterine Cervix | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Squamous cell carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor volume | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Micro-vessel density | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prognosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Uterine cervix | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Moriyama, Shingo
× Moriyama, Shingo× Kotera, Kouhei× Khan, Khaleque Newaz× Sato, Futaba× So, Yoko× Fujishita, Akira× Matsuda, Katsuya× Nakajima, Hisayoshi× Ishimaru, Tadayuki× Masuzaki, Hideaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of the present study was to evaluate the prognostic significance and relationship between tumor volume and microvessel density in squamous cell carcinoma of the uterine cervix. The estimated tumor volume (TV) in 57 patients (22 stage Ib, 18 stage IIa, and 17 stage IIb) had radical hysterectomy was calculated on the assumption that the tumor mass was spheroid. The micro-vessel density (MVD) was evaluated as the ratio of endothelial area immunoreactive to factor-VIII related antigen (von Willebrand factor) to whole image area measured by computer-aided image analysis system. Tumor volume ranged from 0.1 to 41.0 cm3 (median 3.6 cm3) and MVD from 0.33 to 2.95 % (median 0.85 %). A significantly larger median TV was noted in women with positive pelvic node metastasis (6.3 vs 2.6 cm3, P=0.0228), parametrial invasion (8.9 vs 0.8 cm3, P< 0.0001), and postoperative irradiation (5.4 vs 0.6 cm3, P=0.0007). In contrast, these clinical parameters had no effect on MVD. There was no correlation between TV and MVD. The overall survival rate at 5 years was 93.1% and 60.7% (P=0.0037) between women with a TV of ?4 cm3 and >4 cm3, respectively; and 96.2% and 61.3% (P=0.0022) between tissue specimens with a MVD of ?0.8% and >0.8%, respectively. A combined TV of >4 cm3 and MVD >0.8% further deteriorated 5 year survival rate (42.1% vs 94.7%, P<0.0001). Multivariate analysis indicated TV and MVD as independent risk factor in this series (P=0.041, P=0.03, respectively). Our current findings suggested that TV and MVD are independent prognostic factors in women with cervical carcinoma who underwent radical hysterectomy. These prognostic factors may be clinically useful for the selection of high-risk patients who need extensive adjuvant therapy. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 53, 号 4, p. 77-84, 発行日 2009-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.77 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 53(4), pp.77-84 ; 2009 |