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Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors.
http://hdl.handle.net/10069/21637
http://hdl.handle.net/10069/216375fa2acb5-dc5f-4d59-bee8-02ac29b48fa8
名前 / ファイル | ライセンス | アクション |
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Blood113_1639.pdf (384.5 kB)
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Blood113_1639_supplTable.pdf (56.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-27 | |||||
タイトル | ||||||
タイトル | Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Monoclonal gammopathy of undetermined significance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Multiple myeloma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer epidemiology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atomic Bomb Survivors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Iwanaga, Masako
× Iwanaga, Masako× Tagawa, Masuko× Tsukasaki, Kunihiro× Matsuo, Tatsuki× Yokota, Ken-ichi× Miyazaki, Yasushi× Fukushima, Takuya× Hata, Tomoko× Imaizumi, Yoshitaka× Imanishi, Daisuke× Taguchi, Jun× Momita, Sabro× Kamihira, Shimeru× Tomonaga, Masao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radiation exposure is a possible predisposing factor for monoclonal gammopathy of undetermined significance (MGUS), but the association has been uncertain. We investigated the relationship between radiation exposure and MGUS prevalence by using data from the M-protein screening for Nagasaki atomic bomb survivors between 1988 and 2004. Radiation exposure was assessed by exposure distance from the hypocenter and exposure radiation dose. We computed prevalence ratios (PRs) and the 95% confidence intervals (CIs) adjusting for exposure age and sex. A total of 1082 cases of MGUS were identified from 52 525 participants. MGUS prevalence was significantly higher in people exposed at distance within 1.5 km than beyond 3.0 km (PR, 1.4; 95% CI, 1.1-1.9) among those exposed at age 20 years or younger, but it was not found among those exposed at age 20 years or older. MGUS prevalence was also significantly higher in people exposed to more than 0.1 Gy than those exposed to less than 0.01 Gy (PR, 1.7; 95% CI, 1.0-2.8) among those exposed at age 20 years or younger. Thus, people exposed at younger age exhibited a significantly high risk of MGUS when exposed to a high radiation dose. There was no clear association between radiation exposure and the malignant progression of MGUS. Further detailed analysis is needed. | |||||
書誌情報 |
Blood : journal of hematology 巻 113, 号 8, p. 1639-1650, 発行日 2009-02-19 |
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出版者 | ||||||
出版者 | American Society of Hematology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15280020 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00567156 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18849487 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1182/blood-2008-05-159665 | |||||
権利 | ||||||
権利情報 | This research was originally published in Blood. Masako Iwanaga and et.al. Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors. Blood. 2009;113(8): 1639-1650. (c) by the American Society of Hematology | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Blood, 113(8), pp.1639-1650; 2009 |