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Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification
http://hdl.handle.net/10069/21791
http://hdl.handle.net/10069/217912e6dc103-9c09-4ec9-9782-5de579c7d9d4
名前 / ファイル | ライセンス | アクション |
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acta_53_supl_3.pdf (82.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-05-01 | |||||
タイトル | ||||||
タイトル | Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Checkpoint | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Repair | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA double-strand breaks | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yamauchi, Motohiro
× Yamauchi, Motohiro× Suzuki, Keiji× Yamashita, Shunichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is generally accepted that DNA damage checkpoint is the mechanism that allows time for DNA damage repair. However, several lines of evidence challenge this paradigm, especially, in the case of G1 checkpoint. The first evidence is the complete difference between the repair kinetics of DNA double-strand breaks (very rapid) and the timing of G1 checkpoint induction (very slow) after ionizing radiation. The second evidence is that inactivation of p53, which is a central player of G1 checkpoint, does not render cells radiosensitive, rather, such cells become radioresistant. Moreover, it was shown that G1 arrest persists almost permanently after irradiation, until the time when most of the initial damage should be repaired and disappear. Therefore, cells should have a mechanism to maintain G1 checkpoint signaling by amplifying the signal from a limited number of damage. In this review, we discuss what is the bona fide role of G1 arrest and how G1 checkpoint signal is maintained long after irradiation. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 53, 号 supl., p. 3-5, 発行日 2009-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.S3 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 53(supl.), pp.3-5 ; 2009 |