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Allelic Variation in the Circumsporozoite Protein of Plasmodium falciparum from Thai Field Isolates
http://hdl.handle.net/10069/21858
http://hdl.handle.net/10069/2185805d898f4-09b6-4767-a998-9b2fddc16abc
名前 / ファイル | ライセンス | アクション |
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ajtmh51_659.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-05-13 | |||||
タイトル | ||||||
タイトル | Allelic Variation in the Circumsporozoite Protein of Plasmodium falciparum from Thai Field Isolates | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Jongwutiwes, Somchai
× Jongwutiwes, Somchai× Tanabe, Kazuyuki× Hughes, Marianne K.× Kanbara, Hiroji× Hughes, Austin L. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Allelic variation in the Plasmodium falciparum circumsporozoite (CS) protein gene has been examined by sequencing the entire gene in 15 isolates from an endemic area of Thailand. The isolates contain a total of six new allelic forms of the tetrapeptide repeats and eight variants of the T cell epitope (TCE) region of the CS gene. All nucleotide substitutions in the TCE are nonsynonymous. There is no apparent association between the sequence patterns in the repeats and in the TCE. Comparison of the TCE with published sequences has shown that most variants of our isolates are not identical to those found in different geographic areas, suggesting geographic variation in genetic diversity of the CS protein. In a phylogenetic tree, the new Thai alleles did not cluster together, suggesting a considerable heterogeneity within some geographic areas. Furthermore, analyses of tetrapeptide repeats from a number of isolates and strains showed evidence of three genetic mechanisms for the generation of variation in the repeats of the CS gene: point mutation, duplication of one or more repeat units, and intragenic recombination. | |||||
書誌情報 |
American Journal of Tropical Medicine and Hygiene 巻 51, 号 5, p. 659-668, 発行日 1994-11 |
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出版者 | ||||||
出版者 | American Society of Tropical Medicine and Hygiene | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00029637 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00521439 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 7985759 | |||||
権利 | ||||||
権利情報 | Copyright c 1994 by The American Society of Tropical Medicine and Hygiene | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://www.ajtmh.org/cgi/content/abstract/51/5/659 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | American Journal of Tropical Medicine and Hygiene, 51(5), pp.659-668; 1994 |