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Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes
http://hdl.handle.net/10069/19136
http://hdl.handle.net/10069/191366d178238-ed01-40da-942e-bd5952af1f62
名前 / ファイル | ライセンス | アクション |
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RR45_3_399_403.pdf (699.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-12 | |||||
タイトル | ||||||
タイトル | Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA microarray | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypergravity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphorylation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal transduction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okaichi, Kumio
× Okaichi, Kumio× Ide, Miwa× Usui, Aya× Okumura, Yutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the p53 signaling pathway induced by hypergravity in the human glioblastoma cell line A 172. Hypergravity (20×g) induced the accumulation of p53 and the phosphorylation of p53 at Ser-15. The phosphorylation of p53 with hypergravity was not inhibited by wortmannin, the PI3-kinase inhibitor. This indicated that the p53 signal pathway induced by hypergravity is different from other p53 signal pathways, such as that of the DNA damage signal. Hypergravity did not induce an expression of the genes Waf-1 or Bax, located downstream from p53. We also examined the expression of genes with hypergravity by using a DNA microarray containing oligo DNA from 30,000 human genes. Hypergravity (20×g, 6h) did induce the expression of some genes concerned with the cell signaling pathway and cytoskeleton of the cell, but not any of the p53-downstream genes. DNA microarray revealed the induction of many genes to enable the cells to adapt to the hypergravity environment. | |||||
書誌情報 |
Journal of radiation research 巻 45, 号 3, p. 399-403, 発行日 2004-10-10 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 2004, 45(3), p.399-403 |