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Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells
http://hdl.handle.net/10069/19140
http://hdl.handle.net/10069/19140e1b0d294-5115-4ed3-9cb6-f1e5358e09fa
名前 / ファイル | ライセンス | アクション |
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RR48_4_327_333.pdf (993.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-12 | |||||
タイトル | ||||||
タイトル | Effective Suppression of Bystander Effects by DMSO Treatment of Irradiated CHO Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bystander effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DMSO | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reactive oxygen species (ROS) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kashino, Genro
× Kashino, Genro× Prise, Kevin M× Suzuki, Keiji× Matsuda, Naoki× Kodama, Seiji× Suzuki, Minoru× Nagata, Kenji× Kinashi, Yuko× Masunaga, Shin-Ichiro× Ono, Koji× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Evidence is accumulating that irradiated cells produce some signals which interact with non-exposed cells in the same population via a bystander effect. Here, we examined whether DMSO is effective in suppressing radiation induced bystander effects in CHO and repair deficient xrs5 cells. When 1 Gy-irradiated CHO cells were treated with 0.5% DMSO for 1 hr before irradiation, the induction of micronuclei in irradiated cells was suppressed to 80% of that in non-treated irradiated cells. The suppressive effect of DMSO on the formation of bystander signals was examined and the results demonstrated that 0.5% DMSO treatment of irradiated cells completely suppressed the induction of micronuclei by the bystander effect in non-irradiated cells. It is suggested that irradiated cells ceased signal formation for bystander effects by the action of DMSO. To determine the involvement of reactive oxygen species on the formation of bystander signals, we examined oxidative stress levels using the DCFH staining method in irradiated populations. The results showed that the treatment of irradiated cells with 0.5% DMSO did not suppress oxidative stress levels. These results suggest that the prevention of oxidative stress is independent of the suppressive effect of DMSO on the formation of the bystander signal in irradiated cells. It is suggested that increased ROS in irradiated cells is not a substantial trigger of a bystander signal. | |||||
書誌情報 |
Journal of radiation research 巻 48, 号 4, p. 327-333, 発行日 2007-07-15 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 2007, 48(4), p.327-333 |