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Effects of Amino Acids on Malarial Heme Crystallization
http://hdl.handle.net/10069/19217
http://hdl.handle.net/10069/19217533a02a6-4162-4c8d-943b-11c6c3aea5f2
名前 / ファイル | ライセンス | アクション |
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BPB31_1483.pdf (255.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-28 | |||||
タイトル | ||||||
タイトル | Effects of Amino Acids on Malarial Heme Crystallization | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amino acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | beta-hematin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hemozoin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heme | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Dinh, Thanh Uyen
× Dinh, Thanh Uyen× Huy, Nguyen Tien× Dai, Thi Xuan Trang× Nguyen, Thanh Thuy Nhien× Oida, Tatsuo× Hirayama, Kenji× Harada, Shigeharu× Kamei, Kaeko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To gain insight into the mechanism of malarial hemozoin formation and to explore various biological groups for screening novel antimalarial drugs, we examined the effects of amino acids on the formation of β-hematin (BH), which is a synthetic heme crystal structurally identical to hemozoin, in vitro. Our results showed that BH formation was significantly inhibited by basic amino acids (arginine, lysine, and histidine), probably due to the abilities of these amino acids to complex with heme. The results suggest an involvement in the improvement of the blood-schizonticidal activity of 8-quinolinamine when conjugated with basic amino acids. In addition, cysteine also inhibited BH formation, possibly due to its ability to reduce heme iron or decompose heme in acidic conditions. In contrast, BH formation was enhanced by amino acids with high hydrophobicity values (leucine, isoleucine, valine, methionine, and phenylalanine), with the exception of tryptophan at high temperature but was not affected in Tween-induced BH formation under normal physiological conditions. The present results can lead to further research on the development of new antimalarials by conjugating these amino acids, especially basic amino acids, with other substances, or by forming complex or small peptides that could have special effects on BH formation. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 31, 号 8, p. 1483-1488, 発行日 2008-08-01 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18670076 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.31.1483 | |||||
権利 | ||||||
権利情報 | (c) 2008 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 31(8), pp.1483-1488; 2008 |