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Induction of opsonophagocytic killing activity with pneumococcal conjugate vaccine in human immunodeficiency virus-infected Ugandan adults
http://hdl.handle.net/10069/19222
http://hdl.handle.net/10069/192226a13ada6-53d3-4609-8fe5-2dd8f3b7ff8b
名前 / ファイル | ライセンス | アクション |
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Vaccine26_4962.pdf (349.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-09-01 | |||||
タイトル | ||||||
タイトル | Induction of opsonophagocytic killing activity with pneumococcal conjugate vaccine in human immunodeficiency virus-infected Ugandan adults | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumococcal conjugate vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pneumococcal polysaccharide vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serotype-specific IgG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | opsonophagocytic killing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HIV-infected adults | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chen, Meng
× Chen, Meng× Ssali, Francis× Mulungi, Maureen× Awio, Peter× Yoshimine, Hiroyuki× Kuroki, Reiki× Furumoto, Akitsugu× Tanimura, Susumu× Kityo, Cissy× Nagatake, Tsuyoshi× Mugyenyi, Peter× Oishi, Kazunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The levels of IgG determined by ELISA may have limited relevance in human immunodeficiency virus (HIV)-infected adults because of nonfunctional antibodies. 58 HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate vaccine (CV) followed by polysaccharide vaccine (PV) after a two-month interval, and the opsonophagocytic killing (OPK) titers against serotype 4 or 14 pneumococcal strains as well as the levels of serotype-specific IgG in sera were determined. Significant increases were found in the OPK titers and IgG levels for both serotypes after CV vaccination irrespective of HIV status. Increases in IgG levels and OPK titers were largely dependent on the CD4+ cell counts, except for increases in the IgG levels for serotype 4. The proportions with serum OPK titer equal to or greater than 8 were 0-4.3% for serotype 4 and 26.7-42.9% for serotype 14 before vaccination, but the proportions increased up to 43.3-86.2% for serotype 4 and 63.3-96.6% for serotype 14 in all three groups 2 months after CV vaccination. The serum OPK titers remained at levels higher than the pre-vaccination level for at least 8 months after CV vaccination. A single dose of CV could afford some protective immunity in HIV-infected African adults before the introduction of antiretroviral therapy. |
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書誌情報 |
Vaccine 巻 26, 号 38, p. 4962-4968, 発行日 2008-09-08 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10491877 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.vaccine.2008.06.093 | |||||
権利 | ||||||
権利情報 | c 2008 Elsevier Ltd All rights reserved | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Vaccine, 26(38), pp.4962-4968; 2008 |