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DND was also examined in\n4-week-old SHRSPs, which are as yet normotensive, in order to reveal the involvement\nof the development and maintenance of severe hypertension in DND in SHRSPs.\nBefore, during and after occlusion, the blood flow in the hippocampus was\ncontinuously monitored by laser Doppler flowmetry, wherein the probe was connected\nto a plastic fiber that was implanted in the CA1 subfield of animals. The change in\nblood flow was determined by comparing its rate during occlusion to the preoperative\nvalue. DND was confirmed by histological examination at 7 days after the operation.\nThe rate of blood flow during 2-VO was similar between the SHRSPs (42.6% ±\n5.3%) and WKY rats (49.0% ± 14.3%). WKY rats that underwent 4-vessel occlusion\n(4-VO), which induces DND in WKY rats, exhibited a severely decreased blood flow of\n13.7% of the preoperative value. 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Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats
http://hdl.handle.net/10069/19224
http://hdl.handle.net/10069/19224293eec74-e315-4185-96c4-762f0d124931
名前 / ファイル | ライセンス | アクション |
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BraRes1229_204.pdf (455.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-09-01 | |||||
タイトル | ||||||
タイトル | Mild ischemia produces hippocampal neuronal death in stroke-prone spontaneously hypertensive rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuronal death | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hippocampus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SHRSP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | blood flow | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kinugawa, Hidekazu
× Kinugawa, Hidekazu× Sakurai-Yamashita, Yasuko× Niwa, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The blood flow in the hippocampus of stroke-prone spontaneously hypertensive rats (SHRSPs) and Wistar Kyoto (WKY) rats during occlusion of the carotid arteries was examined because it has been previously found that 2-vessel occlusion (2-VO) induces delayed neuronal death (DND) in the pyramidal cells of the CA1 hippocampal area in SHRSPs but not in WKY rats. DND was also examined in 4-week-old SHRSPs, which are as yet normotensive, in order to reveal the involvement of the development and maintenance of severe hypertension in DND in SHRSPs. Before, during and after occlusion, the blood flow in the hippocampus was continuously monitored by laser Doppler flowmetry, wherein the probe was connected to a plastic fiber that was implanted in the CA1 subfield of animals. The change in blood flow was determined by comparing its rate during occlusion to the preoperative value. DND was confirmed by histological examination at 7 days after the operation. The rate of blood flow during 2-VO was similar between the SHRSPs (42.6% ± 5.3%) and WKY rats (49.0% ± 14.3%). WKY rats that underwent 4-vessel occlusion (4-VO), which induces DND in WKY rats, exhibited a severely decreased blood flow of 13.7% of the preoperative value. DND was also observed in 4-week-old SHRSPs that underwent 2-VO, and the incidence was identical to that in 12-week-old SHRSPs. The present results suggest that the DND that occurs in SHRSPs due to 2-VO is not a result of the more severe reduction in blood supply during the occlusion than that in WKY rats, and secondary damage due to severe hypertension but is caused by some genetic factors due to which the pyramidal neurons of SHRSPs are more vulnerable to ischemic insult than those of WKY rats are. |
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書誌情報 |
Brain Research 巻 1229, p. 204-209, 発行日 2008-09-10 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00068993 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0057324X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.brainres.2008.06.105 | |||||
権利 | ||||||
権利情報 | c 2008 Elsevier B.V. All rights reserved | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Brain Research, 1229, pp.204-209; 2008 |