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We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption in the absence of B cells. In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID). Material and Methods: Escherichia coli lipopolysaccharide (LPS) was injected into the gingivae of SCID mice reconstituted by T cells (SCID + T mice). Wild-type C.B-17 mice and SCID mice were used as control animals. Alveolar bone resorption and production of cytokines in the gingivae were then compared histopathologically and immunohistologically. Results: The degree of bone resorption in SCID + T mice was significantly greater than that in SCID mice but less than that in wild-type mice. The same tendency was found for expression of receptor activator of nuclear factor kappaB ligand. The number of interferon-gamma-positive cells in SCID + T mice was the highest of the three groups. In contrast, interleukin-4-positive cells were detected in wild-type mice but not in SCID + T and SCID mice. Conclusion: The results suggest that T cells are able to promote LPS-induced bone resorption in the absence of B cells. 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T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.
http://hdl.handle.net/10069/22315
http://hdl.handle.net/10069/22315623300e8-5f4f-41c0-8a38-36fa3425bb74
名前 / ファイル | ライセンス | アクション |
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JPR43_549.pdf (855.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-11-04 | |||||
タイトル | ||||||
タイトル | T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone resorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lipopolysaccharide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamaguchi, M.
× Yamaguchi, M.× Ukai, Takashi× Kaneko, T.× Yoshinaga, Megumi× Yokoyama, M.× Ozaki, Y.× Hara, Yoshitaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and Objective: T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption in the absence of B cells. In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID). Material and Methods: Escherichia coli lipopolysaccharide (LPS) was injected into the gingivae of SCID mice reconstituted by T cells (SCID + T mice). Wild-type C.B-17 mice and SCID mice were used as control animals. Alveolar bone resorption and production of cytokines in the gingivae were then compared histopathologically and immunohistologically. Results: The degree of bone resorption in SCID + T mice was significantly greater than that in SCID mice but less than that in wild-type mice. The same tendency was found for expression of receptor activator of nuclear factor kappaB ligand. The number of interferon-gamma-positive cells in SCID + T mice was the highest of the three groups. In contrast, interleukin-4-positive cells were detected in wild-type mice but not in SCID + T and SCID mice. Conclusion: The results suggest that T cells are able to promote LPS-induced bone resorption in the absence of B cells. The expressions of cytokines in the presence of B cells are quite different. | |||||
書誌情報 |
Journal of periodontal research 巻 43, 号 5, p. 549-555, 発行日 2008-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16000765 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704381 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18624940 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1600-0765.2008.01083.x | |||||
権利 | ||||||
権利情報 | (c) 2008 Blackwell Munksgaard | |||||
権利 | ||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Periodontal Research, 43(5), pp.549-555; 2008 |