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Hormonal activity of polycyclic musks evaluated by reporter gene assay.
http://hdl.handle.net/10069/20086
http://hdl.handle.net/10069/2008628523d14-6c06-425f-93a4-251143400a32
名前 / ファイル | ライセンス | アクション |
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es_14_4_195.pdf (354.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-10-09 | |||||
タイトル | ||||||
タイトル | Hormonal activity of polycyclic musks evaluated by reporter gene assay. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polycyclic musk | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | androgen receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid hormone receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hormonal effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mori, Taiki
× Mori, Taiki× Iida, Mitsuru× Ishibashi, Hiroshi× Kohra, Shinya× Takao, Yuji× Takemasa, Takehiro× Arizono, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Synthetic musk fragrance compounds, such as polycyclic musks (PCMs), are a group of chemicals used extensively as personal care products, and can be found in the environment and the human body. PCMs, such as 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexa-methylcyclopenta-gamma-2-benzopyran (HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyltetralin (AHTN), are known to have agonistic activities toward human estrogen receptor alpha (hERalpha) and hERbeta, and have antagonistic activity toward the human androgen receptor (hAR), as shown in several reporter gene assays. However, little is known about the interaction of PCMs with the human thyroid hormone receptor (hTR), and the hormonal effects of other PCMs except for HHCB and AHTN. In this study, we focus on the interactions of six PCMs, namely, HHCB, AHTN, 4-acetyl-1,1-dimethyl-6-tert-butyl-indan (ADBI), 6-acetyl-1,1,2,3,3,5-hexamethylindan (AHMI), 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone (DPMI), and 5-acetyl-1,1,2,6-tetramethyl-3-isopropy-lindan (ATII) with hERalpha, hAR, and hTRbeta by in vitro reporter gene assay using Chinese hamster ovary cells. All the samples were found to be agonists toward hERalpha, whereas no agonistic activities of these PCMs for hAR and hTRbeta were observed. No antagonistic activities for hERalpha and hTRbeta were observed at the concentrations tested. However, several PCMs, namely, HHCB, AHTN, ATII, ADBI, and AHMI, showed dose-dependent antagonistic activities for hAR, and the IC50 values of these compounds were estimated to be 1.0 x 10(-7), 1.5 x 10(-7), 1.4 x 10(-7), 9.8 x 10(-6), and 1.4 x 10(-7) M, respectively. The results suggest that these PCMs interact with hERalpha and hAR but have no hormonal effect on hTRbeta. This is the first report on the agonistic and antagonistic activities of ATII, ADBI, AHMI, and DPMI for hERalpha and hAR as determined by in vitro reporter gene assay using stably transfected Chinese hamster ovary cells. | |||||
書誌情報 |
Environmental sciences : an international journal of environmental physiology and toxicology 巻 14, 号 4, p. 195-202, 発行日 2007 |
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出版者 | ||||||
出版者 | MYU | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0915955X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10861036 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17762842 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://www.myu-inc.jp/myukk/ES/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Environmental sciences, 14(4), pp.195-202; 2007 |