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In vitro reactivation of human immunodeficiency virus-1 upon stimulation with scrub typhus rickettsial infection.
http://hdl.handle.net/10069/20126
http://hdl.handle.net/10069/201269d053a50-96de-4ae2-9402-815539952f58
名前 / ファイル | ライセンス | アクション |
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ajtmh68_557.pdf (146.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-10-21 | |||||
タイトル | ||||||
タイトル | In vitro reactivation of human immunodeficiency virus-1 upon stimulation with scrub typhus rickettsial infection. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Moriuchi, Masako
× Moriuchi, Masako× Tamura, Akira× Moriuchi, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | While a number of microbial infections induce a transient burst in viral load in individuals infected with human immunodeficiency virus-1 (HIV-1), a recent study has suggested that scrub typhus may suppress HIV-1 infection. We investigated the effects of Orientia tsutsugamushi on HIV-1 infection. In vitro HIV-1 infection experiments were conducted using peripheral blood mononuclear cells (PBMC) acutely infected with R5 and X4 HIV-1 or PBMC derived from patients receiving highly active antiretroviral therapy (HAART) whose plasma viral load was undetectable. Stimulation of PBMC with O. tsutsugamushi induced production of proinflammatory cytokines and {beta}-chemokines, and markedly down-regulated expression of CCR5. Although pretreatment with O. tsutsugamushi rendered PBMC resistant to R5 HIV-1, it otherwise enhanced HIV-1 replication. Stimulation by O. tsutsugamushi induced HIV-1 replication in PBMC from patients receiving HAART. These findings suggest that scrub typhus does not necessarily suppress HIV-1 infection and does have potential to enhance HIV-1 replication. | |||||
書誌情報 |
American Journal of Tropical Medicine and Hygiene 巻 68, 号 5, p. 557-561, 発行日 2003-05 |
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出版者 | ||||||
出版者 | American Society of Tropical Medicine and Hygiene | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00029637 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00521439 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12812345 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2003 by The American Society of Tropical Medicine and Hygiene | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://www.ajtmh.org/cgi/content/abstract/68/5/557 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | American Journal of Tropical Medicine and Hygiene, 68(5), pp.557-561; 2003 |