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蛍光検出高速液体クロマトグラフィーによるマウス脳内バルプロ酸の定量とその薬理学への応用
http://hdl.handle.net/10069/20212
http://hdl.handle.net/10069/202121a63514e-124a-4765-9e91-3c15b213b92e
名前 / ファイル | ライセンス | アクション |
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bunseki38_11_t174.pdf (450.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-18 | |||||
タイトル | ||||||
タイトル | 蛍光検出高速液体クロマトグラフィーによるマウス脳内バルプロ酸の定量とその薬理学への応用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fluorometric HPLC | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | valproic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glutamate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-aminobutyrate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aspartate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics of valproic acid in the brain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
松山, 賢治
× 松山, 賢治× 宮崎, 長一郎× 山下, 達也× 市川, 正孝 |
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著者別名 | ||||||
姓名 | Matsuyama, Kenji | |||||
著者別名 | ||||||
姓名 | Miyazaki, Choichiro | |||||
著者別名 | ||||||
姓名 | Yamashita, Tatsuya | |||||
著者別名 | ||||||
姓名 | Ichikawa, Masataka | |||||
その他のタイトル | ||||||
その他のタイトル | Fluorometric determination of valproic acid in mouse brain by HPLC and applications to pharmacology. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | マウスに対してバルプロ酸(VPA)200mg/kgを腹くう内投与した後,HPLCを用いて脳内及び血中のVPA蛍光定量を行った.同時にVPA投与により引き起こされる脳内アミノ酸,4-アミノ酪酸(GABA),アスパラギン酸塩及びグルタミン酸の変化を検討した.その結果,VPAの抗てんかん作用は抑制性アミノ酸であるGABAの有意な上昇と同時に,興奮性アミノ酸であるアスパラギン酸とグルタミン酸の有意な減少に基づくものであることが実証された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A fluorometric HPLC method for the determination of valproic acid (VPA) in mouse brain was developed using 3-bromomethyl-6, 7-dimethoxy-l-methyl-2 (1H) -quino-xalinone (Br-DMEQ) as a prelabelling reagent. The method was used to study the interrelations among the concentrations of VPA, 7-aminobutyrate as an inhibitory amino acid and glutamate or aspartate as an excitatory amino acid in mouse brain. The brain levels of VPA decreased with a half life of 0.99 h and attained almost zero at 5 h after the intraperitoneal administration of VPA at a dose of 200 mg/kg to mice. The administration of VPA gave rise to a significant increase in γ-aminobutyrate in response to a significant decrease in aspartate and glutamate in mouse brain. In particular, aspartate continued to decrease up to 8 h after administration whereas VPA disappeared at 5 h. The present observations are considered closely correlated to the "carried over effect" of VPA. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | <特集>バイオアナリティカルケミストリー | |||||
書誌情報 |
分析化学 巻 38, 号 11, p. T174-T178, 発行日 1989-11-15 |
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出版者 | ||||||
出版者 | 社団法人日本分析化学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05251931 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00222633 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://ci.nii.ac.jp/naid/110002909907/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 分析化学. 38(11), pp.T174-T178; 1989 |