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Correlation Between Preeclampsia and Prevalence of Polymorphism of Angiotensinogen, Methyleneteterahydrofolate Reductase and Factor V, Prothrombin Genes Among Japanese Women
http://hdl.handle.net/10069/20794
http://hdl.handle.net/10069/20794dc5cea24-22de-4a2b-bdcf-11c5f74d3b08
名前 / ファイル | ライセンス | アクション |
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acta_53_2_37.pdf (561.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-12-08 | |||||
タイトル | ||||||
タイトル | Correlation Between Preeclampsia and Prevalence of Polymorphism of Angiotensinogen, Methyleneteterahydrofolate Reductase and Factor V, Prothrombin Genes Among Japanese Women | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Preeclampsia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiotensinogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methlenetetrahydrofolate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Factor V | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prothrombin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yoshida, Atsushi
× Yoshida, Atsushi× Miura, Kiyonori× Nakayama, Daisuke× Masuzaki, Hideaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJJECTIVE: To determine the genotypes of four candidate genes in Japanese women with a history of preeclampsia, and in a control group of parous woman. STUDY DESIGN: Fifty-two pregnant women with a history of preeclampsia in their first pregnancy and 113 normotensive gravid women were studied. All subjects were Japanese women with singleton gestations. Genomic DNA was extracted, and genotypes of angiotensinogen (AGT), methyleneteterahydofolate reductase (MTHFR), factor V Leiden, and prothrombin genes were analyzed. RESULTS: The frequencies of homozygous AGT gene mutation and homozygous MTHFR gene mutation in preeclampsia were significantly higher than that in control. The calculated risk associated with the presence of both mutations did not exceed the risk with polymorphism of each gene. None of the examined cases showed polymorphism of factor V Leiden and prothrombin G20210A genes. CONCLUSION: In Japanese patients with preeclampsia, the angiotensinogen gene and particularly MTHFR gene may play a role in the pathogenesis of preeclampsia. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 53, 号 2, p. 37-41, 発行日 2008-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/53.37 | |||||
sortkey | ||||||
2 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 53(2), pp.37-41 ; 2007 |