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Disinhibitory involvement of the anterior cingulate cortex in the descending antinociceptive effect induced by electroacupuncture simulation in rats
http://hdl.handle.net/10069/18701
http://hdl.handle.net/10069/18701fb71992f-6182-45de-a994-550214a9556a
名前 / ファイル | ライセンス | アクション |
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AJCM36_569.pdf (234.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-07-08 | |||||
タイトル | ||||||
タイトル | Disinhibitory involvement of the anterior cingulate cortex in the descending antinociceptive effect induced by electroacupuncture simulation in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acupuncture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anterior cingulate cortex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Disinhibition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Periaqueductal gray matter | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Opioid peptides | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zeredo, Jorge L
× Zeredo, Jorge L× Hirano, Takafumi× Kimoto, Mari× Moritaka, Kentaro× Nasution, Fajar H× Toda, Kazuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was conducted to clarify the role of the anterior cingulate cortex (ACCX) in acupuncture analgesia. Experiments were performed on 35 female Wistar albino rats weighing about 300 g. Single unit recordings were made from ACCX neurons with a tungsten microelectrode. Descending ACCX neurons were identified by antidromic activation from electrical shocks applied to the ventral part of the ipsilateral PAG through a concentric needle electrode. Cathodal electroacupuncture stimulation of Ho-Ku (0.1 ms in duration, 45 Hz) for 15 min was done by inserting stainless steel needles bilaterally. An anodal silver-plate electrode (30 mm x 30 mm) was placed on the center of the abdomen. Naloxone (1.0 mg/kg, i.v.) was used to test whether changes of ACCX activities were induced by the endogenous opioid system or not. Data were collected from a total of 73 ACCX neurons. Forty-seven neurons had descending projection to the PAG, and 26 had no projections to the PAG. A majority of descending ACCX neurons were inhibited by electroacupuncture stimulation. By contrast, non-projection ACCX neurons were mainly unaffected by electroacupuncture. Naloxone did not reverse acupuncture effects on the changes of ACCX neuronal activities. Acupuncture stimulation had predominantly inhibitory effects on the activities of descending ACCX neurons. Since the functional connection between ACCX and 3/21 PAG is inhibitory, electroacupuncture caused disinhibition of PAG neurons, whose activity is closely related to descending antinociception to the spinal cord. This disinhibitory effect elicited by acupuncture stimulation is thought to play a significant role in acupuncture analgesia. |
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書誌情報 |
American Journal of Chinese Medicine 巻 36, 号 3, p. 569-577, 発行日 2008 |
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出版者 | ||||||
出版者 | World Scientific Publishing Co | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0192415X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00066285 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1142/S0192415X08005989 | |||||
権利 | ||||||
権利情報 | copyright World Scientific Publishing Company | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | American Journal of Chinese Medicine, 36(3), pp.569-577; 2008 |