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Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs
http://hdl.handle.net/10069/18813
http://hdl.handle.net/10069/188130cce485c-5935-44f2-9092-f64b2a4a0433
名前 / ファイル | ライセンス | アクション |
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RR46_2_197_203.pdf (753.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-11 | |||||
タイトル | ||||||
タイトル | Differences in Effects of Oncogenes on Sensitivity to Anticancer Drugs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oncogene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SHOK cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemosensitivity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IC_<50> | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamamoto, Tomoyuki
× Hamamoto, Tomoyuki× Suzuki, Keiji× Sasaki, Hitoshi× Ichikawa, Masataka× Kodama, Seiji× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC_<50> of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c-myc, v-mos, or v-fgr gene increased their sensitivity to bleomycin, while those transfected with the H-ras gene developed resistance. Resistance to cisplatin was conferred by the introduction of the H-ras or c-cot gene. In the case of adriamycin, the c-myc or c-cot transfectant increased sensitivity and the H-ras transfectant decreased it. Mitomycin C resistance was observed by the introduction of the K-ras gene. Thus, the H-ras gene was found to be involved in the development of resistance to three of the four anticancer drugs. In addition, we have for the first time shown that mos and cot have an effect on sensitivity to three and all of the four anticancer drugs, respectively. These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity. | |||||
書誌情報 |
Journal of radiation research 巻 46, 号 2, p. 197-203, 発行日 2005-06-30 |
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出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 04493060 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | 日本放射線影響学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of radiation research. 2005, 46(2), p.197-203 |