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Comparative analyses of CTX prophage region of Vibrio cholerae seventh pandemic wave 1 strains isolated in Asia
http://hdl.handle.net/10069/39247
http://hdl.handle.net/10069/392474c327dc1-becd-4d05-b7bf-cde2519e3131
名前 / ファイル | ライセンス | アクション |
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ISYK1126_Pham.pdf (1.4 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2019-06-20 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comparative analyses of CTX prophage region of Vibrio cholerae seventh pandemic wave 1 strains isolated in Asia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholera toxin prophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phylogenetic tree | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | seventh pandemic wave 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vibrio cholerae O1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
PHAM, DUC THO
× PHAM, DUC THO |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Vibrio cholerae O1 causes cholera, and cholera toxin, the principal mediator of massive diarrhea, is encoded by ctxAB in the cholera toxin (CTX) prophage. In this study, the structures of the CTX prophage region of V. cholerae strains isolated during the seventh pandemic wave 1 in Asian countries were determined and compared. Eighteen strains were categorized into eight groups by CTX prophage region-specific restriction fragment length polymorphism and PCR profiles and the structure of the region of a representative strain from each group was determined by DNA sequencing. Eight representative strains revealed eight distinct CTX prophage regions with various combinations of CTX-1, RS1 and a novel genomic island on chromosome I. CTX prophage regions carried by the wave 1 strains were diverse in structure. V. cholerae strains with an area specific CTX prophage region are believed to circulate in South-East Asian countries; additionally, multiple strains with distinct types of CTX prophage region are co-circulating in the area. Analysis of a phylogenetic tree generated by single nucleotide polymorphism differences across 2483 core genes revealed that V. cholerae strains categorized in the same group based on CTX prophage region structure were segregated in closer clusters. CTX prophage region-specific recombination events or gain and loss of genomic elements within the region may have occurred at much higher frequencies and contributed to producing a panel of CTX prophage regions with distinct structures among V. cholerae pathogenic strains in lineages with close genetic backgrounds in the early wave 1 period of the seventh cholera pandemic. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1126号 学位授与年月日:平成31年3月6日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: Tho Duc Pham, Tuan Hai Nguyen, Hanako Iwashita, Taichiro Takemura, Kouichi Morita and Tetsu Yamashiro | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Microbiology and Immunology, 62(10), pp.635-650; 2018 | |||||
書誌情報 |
Microbiology and Immunology 巻 62, 号 10, p. 635-650, 発行日 2019-03-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855600 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/1348-0421.12648 | |||||
権利 | ||||||
権利情報 | c 2018 The Authors. Microbiology and Immunology published by The Societies and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | アジア地域より分離されたVibrio cholerae 第7次パンデミック wave 1株のCTX prophage 領域の比較解析 | |||||
出版者 | ||||||
出版者 | John Wiley & Sons Australia, Ltd | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/39015 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-03-06 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第1126号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2019-03-06) |