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Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
http://hdl.handle.net/10069/18972
http://hdl.handle.net/10069/189725932da19-8627-4e73-938a-764f6f8d3070
名前 / ファイル | ライセンス | アクション |
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JNSV53_287.pdf (172.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-08-12 | |||||
タイトル | ||||||
タイトル | Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proanthocyanidins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligomers | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antioxidant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | persimmon | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Lee, Young A
× Lee, Young A× Cho, Eun Ju× Tanaka, Takashi× Yokozawa, Takako |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC_<50> values of 4.35 and 2.41μg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against α-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of α-amylase activity would probably depend on the degree of polymerization. On the other hand, against α-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems. | |||||
書誌情報 |
Journal of nutritional science and vitaminology 巻 53, 号 3, p. 287-292, 発行日 2007-06 |
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出版者 | ||||||
出版者 | 日本ビタミン学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03014800 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00703822 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3177/jnsv.53.287 | |||||
権利 | ||||||
権利情報 | 日本ビタミン学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of nutritional science and vitaminology, 53(3), p.287-292; 2007 |