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Motor End-Plate Fine Structure of Red and White Muscles in Experimental Autoimmune Myasthenia Gravis
http://hdl.handle.net/10069/17474
http://hdl.handle.net/10069/17474e3d9fe68-f5a8-4d99-be1b-dac7a1f24657
名前 / ファイル | ライセンス | アクション |
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acta31_01-04_04_t.pdf (8.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-06-20 | |||||
タイトル | ||||||
タイトル | Motor End-Plate Fine Structure of Red and White Muscles in Experimental Autoimmune Myasthenia Gravis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Experimental autoimmune myasthenia gravis (EAMG) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myasthenia gravis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Motor end-plate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Morphometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | White and red muscles | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Satoh, Akira
× Satoh, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neuromuscular junction ultrastructure in rat forelimb digit extensor muscle (FDE), extensor digitorum longus (EDL) and soleus (SOL) was quantitatively investigated in experimental autoimmune myasthenia gravis (EAMG). Experimental animals were immunized with highly purified Narke Japonica acetylcholine receptor protein plus complete Freund's adjuvant and B. pertussis vaccine : control animals received only adjuvant and vaccine. Between day 7 and 11 (acute phase) mononuclear cells infiltrated those regions of muscle where the end-plates were located and there was intense destruction of postsynaptic regions and most postsynaptic regions were splitted away from the underlying muscle fibers in FDE and EDL. In contrast, most postsynaptic folds were not detached from the underlying muscle fibers in SOL. Subsequently, between day 30 to 33 (chronic phase) morphometric analysis revealed that the postsynaptic regions of FDE and EDL were simpler and destructed more intensely than those of SOL These results indicate that the intensity of destruction of the postsynaptic region in EAMG is apparently different between type I fibers and type II fibers both in acute phase and chronic phase. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 31, 号 1/4, p. 41-58, 発行日 1986-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00041-P00058 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia. 1986, 31(1-4), p.41-58 |