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Flow Cytometric Analysis of the Cellular DNA Content in Various Liver Diseases
http://hdl.handle.net/10069/17547
http://hdl.handle.net/10069/17547977b969e-4cb7-468e-9423-91dba45e96c4
名前 / ファイル | ライセンス | アクション |
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acta37_01-04_02_t.pdf (468.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-06-20 | |||||
タイトル | ||||||
タイトル | Flow Cytometric Analysis of the Cellular DNA Content in Various Liver Diseases | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Omagari, Katsuhisa
× Omagari, Katsuhisa× Imanishi, Takeo× Makiyama, Kazuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Flow cytometric analysis of the cellular DNA content was conducted using paraffin-embedded liver tissues. Of the 488 cases examined, 413 (84.6%) cases were suitable for analysis. Of these, 296 (88.9%) were diploid and 37 (11.1%) were aneuploid. The ploidy pattern was unaffected by patients' sex and age. Long-term stored tissues were as suitable for analysis as short-term stored ones. An aneuploid pattern was more frequently found in hepatocellular carcinoma (HCC) (17/43,39.5%) than in non-neoplastic liver conditions (20/284,7.0%) (p<0.01). The ploidy pattern was determined to be one of the most important prognostic factors in HCC. An aneuploid pattern was also found in non-neoplastic liver conditions such as liver cirrhosis (LC) and chronic hepatitis caused by hepatitis virus (CH). It seems that the ploidy pattern and proliferative index (S+G2M fraction) do not always affect carcinogenesis in non-neoplastic liver conditions. Thus, flow cytometric analysis of the cellular DNA content using paraffin-embedded specimens is useful for determining the prognostic significance in HCC, although the significance is uncertain in non-neoplastic liver conditions. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 37, 号 1/4, p. 5-8, 発行日 1992-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00005-P00008 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia. 1992, 37(1-4), p.5-8 |