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Two-Color Immunofluorescene and Flow Cytometric Analysis of Peripheral Blood Lymphocyte Subsets in Aging Humans
http://hdl.handle.net/10069/17587
http://hdl.handle.net/10069/17587127662bd-eb05-41b1-8f58-3e2674b84bc0
名前 / ファイル | ライセンス | アクション |
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acta37_01-04_42_t.pdf (607.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-06-20 | |||||
タイトル | ||||||
タイトル | Two-Color Immunofluorescene and Flow Cytometric Analysis of Peripheral Blood Lymphocyte Subsets in Aging Humans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphocyte subsets ; aging ; flow cytometry | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Senju, Masahiro
× Senju, Masahiro× Makiyama, Kazuya× Oda, Hidetosi× Nakamuta, Koji× Omagari, Katsuhisa× Itsuno, Minoru× Hara, Kohei |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using two-color immunofluorescence, multiparameter flow cytometry has been used to examine the antigenic characteristics of the nature of changes due to aging in lymphocyte subests. The percentage and absolute numbers of T cells (CD3+T) declined in the aging humans. This decline was associated with a decreasing trend of CD8+T (cytotoxic/suppressor) cells in aging. The aged men had a slight but non-significant increased proportion of CD4+Leu8-T cells, which mediate the helper functions in B cell differentiation in association with an increasing tendency in the number of CD4+ T cells. A wide variety of changes took place in activated T cells expressing antigens such as Leu17(CD38), HLA-DR, or HLA-DQ, Although the decrease in the number of total CD8+ T cells was only slight, the proportion of CD8+ cell bearing Leu7 (CD57) antigen was strikingly increased in the elderly. For NK cells, a total number of NK cells (Leu19+CD3-) in the aged subjects was increased, but a subpopulation of cells having the high NK activity (Leu19+CD57-cells) decreased in the elderly men. The present study revealed various changes in lymphocyte subsets in aging humans. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 37, 号 1/4, p. 190-194, 発行日 1992-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00190-P00194 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia. 1992, 37(1-4), p.190-194 |