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Assessment of Malignant Potential and Prognostic Correlation in Colorectal Carcinomas Using Monoclonal Antibody Ki-67.
http://hdl.handle.net/10069/17596
http://hdl.handle.net/10069/17596ed3ba3f9-10fb-4746-b631-8f565bd4099c
名前 / ファイル | ライセンス | アクション |
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acta38_01_02_t.pdf (2.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-06-20 | |||||
タイトル | ||||||
タイトル | Assessment of Malignant Potential and Prognostic Correlation in Colorectal Carcinomas Using Monoclonal Antibody Ki-67. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kawazoe, Naoki
× Kawazoe, Naoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The growth fraction in 103 patients with colorectal carcinoma was determined using immunohistochemical staining with the monoclonal antibody Ki-67. The results were correlated with histopathologic findings and clinical outcome. Carcinomas showed a wide range of Ki-67 labeling index (LI), reflecting variation in proliferative activity. Ki-67 LI values paralleled those of the Mitotic Index and DNA polymerase α LI, but were not consistent with the results of DNA flow cytometric analysis, Ki-67 LI was significantly lower in carcinomas confined to the mucosa and submucosa than in those invading the muscularis propria. Poorly differentiated carcinomas demonstrated significantly high LI compared with those that were moderate of well differentiated. Ki-67 LI was particularly higher in carcinomas with Iymphatic invasion and/or venous invasion than those without invasion. No correlation of Ki-67 LI with lymph node metastasis or liver metastasis could be found. Four recurrent cases had significantiy high LI as compared with gighty-six cases with primary colorectal carcinoma. Carcinomas with high Ki-67 LI (greater than 30%) implicated in poor prognosis, whereas those with low Ki-67 LI demonstrated favorable prognosis. Immunohistochemical staining of proliferating cells using the Ki-67 monoclonal antibody in not only colorectal carcinomas but also other carcinomas is useful for assessing malignant potential and prognosis. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 38, 号 1, p. 9-14, 発行日 1993-01-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00009-P00014 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia. 1993, 38(1), p.9-14 |