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The relationship between p53, c-myc product expression and clinicopathological parameters in primary breast carcinomas
http://hdl.handle.net/10069/16002
http://hdl.handle.net/10069/160022619ad0e-60b5-45c2-bacc-f358e8c17218
名前 / ファイル | ライセンス | アクション |
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acta39_01_41_t.pdf (741.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | The relationship between p53, c-myc product expression and clinicopathological parameters in primary breast carcinomas | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Uchikawa, Tetsuya
× Uchikawa, Tetsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Sixty-four primary breast carcinomas were analyzed by flow cytometry for their expression of p53 and c-myc proteins. c-myc protein expression was correlated with pathological infiltration (p = 0.05), but the other parameters (tumor size, lymph node status, menopausal status, steroid receptor status, and histological type) were not statistically correlated. On the other side, p53 protein expression was significantly correlated with large tumor size (p = 0.0001) and lymph node metastasis positive (p = 0.001), and weakly correlated with post menopausal status (p <0.01) and pathological infiltration (p = 0.01). Although there was no correlation between only p53 protein oevr-expression and disease free survival. but when p53 protein over-expression and c-myc protein oevr-expression were simultaneously found in the same tumor-cell population, prognosis of these cases were poor. Namely simultaneous over-expression of p53 protein and c-myc protein was found in 22 cases, 7 of 22 (31.8%) have had a relapse. In other 2 cases relapse was found, but both these cases were medullary carcinoma and the level of expression of p53, and c-myc protein was low. This study indicates that plural gene product expression should be simultaneously analyzed when investigate the prognostic markers in breast carcinomas. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 1-3, p. 198-203, 発行日 1994-10-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00198-P00203 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(1-3), p.198-203 |