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Experimental-Induced Colitis in Rats by Ethanolic Solution of Trinitrobenzene Sulfonic Acid and Ethanol Alone : A Comparative Study
http://hdl.handle.net/10069/16003
http://hdl.handle.net/10069/1600363f2a290-e101-4adb-8bfc-9e62e4382464
名前 / ファイル | ライセンス | アクション |
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acta39_04_01_t.pdf (2.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Experimental-Induced Colitis in Rats by Ethanolic Solution of Trinitrobenzene Sulfonic Acid and Ethanol Alone : A Comparative Study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Zea-Iriarte, Walter
× Zea-Iriarte, Walter× Makiyama, Kazuya× Itsuno, Minoru× Umene, Yoshihiko× Hara, Kohei |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Epidemiological data suggest an increase in both developed and undeveloped countries of inflammatory bowel disease. Furthermore, its etiology and pathophysiology remain unknown. Appropriated animal models are needed. We have studied a rat model of hapten-induced chronic colitis. In Wistar rats, intracolonic instillation of 20 mg or 42 mg of the hapten trinitrobenzene sulfonic acid in 30 % and 40 % ethanol proved to induce chronic colitis after 14 to 21 days of administration, in dose-dependent fashion when compared with ethanol alone that induced only acute colitis after three days of administration. This chronic colitis shares some characteristics with inflammatory bowel disease in humans, specially with Crohn's disease, such as transmural inflammation, development of strictures, ulcerations and infiltration of inflammatory cells throughout the colonic wall. These features make this model suitable for further studies of intestinal inflammation. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 1-10, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00001-P00010 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.1-10 |