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Relationship between the Responses to Simultaneous Double Staining for Ki-67 and AgNOR and the Clinicopathological Features of Non-Small Cell Pulmonary Carcinoma
http://hdl.handle.net/10069/16027
http://hdl.handle.net/10069/16027eeb5d1cb-a7ec-4f85-aaa8-8659682ea333
名前 / ファイル | ライセンス | アクション |
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acta39_04_25_t.pdf (5.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Relationship between the Responses to Simultaneous Double Staining for Ki-67 and AgNOR and the Clinicopathological Features of Non-Small Cell Pulmonary Carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yamaguchi, Shinya
× Yamaguchi, Shinya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Samples of stage I to III non-small cell pulmonary carcinoma, resected from 51 patients, were simultaneously doublestained for Ki-67 and AgNOR (argyrophil nucleolar organizer region). The responses to the staining was analyzed in relation to the stage, degree of histological differentiation, extent of pulmonary tumor (factor T), extent of lymph node metastasis (factor N) and DNA ploidy of non-small cell pulmonary carcinoma. The AgNOR count was significantly higer for Ki-67 positive cells than for Ki-67 negative cells. The Ki-67 positive rate, the AgNOR count in Ki-67 positive cells and the AgNOR count in Ki-67 negative cells differed significantly between stage I and III. The only significant difference observed between well differentiated carcinoma and poorly differentiated carcinoma was the Ki-67 positive rate. When analyzed in more detail, factor T was found to have no correlation with the Ki-67 positive rate. The AgNOR count in Ki-67 positive cells was significantly elevated only in T4 cases which are thought to have a very poor prognosis. When factor N was analyzed, there were significant differences between N1 and N2 cases in terms of the Ki-67 positive rate and the AgNOR count in Ki-67 positive cells. The Ki-67 positive rate and AgNOR count in Ki-67 positive cells were significantly high in N2 and N3 cases. When the AgNOR count was divided into more categories, all cases with less than 18 AgNOR count in Ki-67 positive cells were rated as NO or N1, while most cases with 20 or more AgNOR count were rated as N2 or N3. These results demonstrate the usefulness of simultaneous double staining for Ki-67 and AgNOR as a means of assessing the biological mailgnancy level of non-small cell pulmonary carcinoma. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 39, 号 4, p. 147-152, 発行日 1994-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00147-P00152 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1994, 39(4), p.147-152 |