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In Vivo Ocular Pharmacokinetic Model for Designing Dosage Schedules and Formulations of Ophthalmic Drugs in Human
http://hdl.handle.net/10069/16091
http://hdl.handle.net/10069/1609101e9541c-b07f-41a2-ba7f-053460b0af3e
名前 / ファイル | ライセンス | アクション |
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acta42_03_08_t.pdf (676.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | In Vivo Ocular Pharmacokinetic Model for Designing Dosage Schedules and Formulations of Ophthalmic Drugs in Human | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | timolol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diffusion model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ocular penetration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug delivery system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Sasaki, Hitoshi
× Sasaki, Hitoshi× Yamamura, Kenzo× Mukai, Takahiro× Nishida, Koyo× Nakamura, Junzo× Nakashima, Mikiro× Ogasawara, Masayoshi× Ichikawa, Masataka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study was to develop an in vivo pharmacokinetic model and parameters for predicting the concentrations of ophthalmic drugs in the anterior chamber after instillation into human eyes. We have already reported the usefulness of mathematical model including a diffusion process in rabbits 1). Timolol was used as a model ophthalmic drug. The concentrations of timolol and fluorescein in the tear fluid were determined after instillation into the eyes of human volunteers. The in vivo pharmacokinetic parameters in the tear fluid were estimated by the elimination profile according to a one-compartment model. The concentrations of timolol in the aqueous humor were obtained from the data previously reported 2),3). Other parameters of timolol were estimated from the concentration profiles of timolol in the aqueous humor according to a pharmacokinetic model including a corneal diffusion process. The parameters for human were almost equal to those for rabbits reported previously 1). This mathematical model and in vivo parameters will be effective to estimate the adequate regimen for ophthalmic chemotherapy and develop the ocular drug delivery systems. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 42, 号 3-4, p. 45-50, 発行日 1997-12-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00045-P00050 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1997, 42(3-4), p.45-50 |