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Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand
http://hdl.handle.net/10069/16102
http://hdl.handle.net/10069/161020740ed40-f7f1-414d-b1cb-fc01e46a26a2
名前 / ファイル | ライセンス | アクション |
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acta43_01_06_t.pdf (671.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Molecular Analysis of Common Types ofホア-Thalassemia Associated with(ホイ-Thalassemia in Northern Thailand | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | a -thalassemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | R -thalassemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymerase chain reaction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anemia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kudeken, Mika
× Kudeken, Mika× Asato, Tsuyoshi× Tsuda, Satoshi× Nakashima, Yasutsugu× Takei, Hiroshi× Buasaengchan, Suwanna× Makonkawkeyoon, Luksana |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We applied PCR strategies to detect the common types of ホア- thalassemia determinants which were associated with ホイ- thalassemia in northern Thailand. Two types of deletions in the ホア-globin gene locus;the 18 kb deletion of Southeast Asian type(-ホアSEA)and the 3.7 kb rightward deletion(-ホア3.7), and the most prevalent non-deletion mutation, Hb Constant Spring(ホアC8, TAA to CAA at the codon 141)were investigated in 22 cases of ホイ-thalassemia. Nine ホイ-thalassemia patients were found to be associated with one or two of these defective ホア-globin gene determinants and the mean hemoglobin concentration in these patients was 6.3 ツア 1.1 g/dl whereas it was 5.6ツア.0.8 g/dl in 12 ホイ-thalassemia patients without ホア- globin gene abnormalities ; the difference is statistically insignificant (p = 0.08). The level of anemia was severe in the ホイ-thalassemia patients carrying a single ホア-globin gene abnormality in the heterozygous compounds ; whereas the (ホイ-thalassemias withホア-globin gene defects in both alleles showed less severe anemia. A patient carrying the ホア ・」8 determinant in homozygous compound showed the highest hemoglobin level among these ホイ-thalassemia patients. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 43, 号 1-2, p. 33-37, 発行日 1998-06-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00033-P00037 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1998, 43(1-2), p.33-37 |