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Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide
http://hdl.handle.net/10069/16116
http://hdl.handle.net/10069/16116abdd2d5a-868c-4fe5-ad13-43cda89dd8eb
名前 / ファイル | ライセンス | アクション |
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acta43_03_07_t.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Platelet Serotonin (5-HT)2A Receptor Binding Sites in Affective Disorders: A Quantitative Receptor Autoradiographic Study with [ 125I ] Lysergic Acid Diethylamide | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-HT2A receptors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | platelet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | affective disorders | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quantitative receptor autoradiography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | [ 1 25IL] SD | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tsujimura, Toru
× Tsujimura, Toru× Asou, Tadafumi× Hayashida, Masaki× Himeno, Akihiko× Nakane, Yoshibumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We used the quantitative receptor autoradiographic method with a radioligand of [ 125I ]lysergic acid diethylamide ([125I]LSD) to quantitate platelet serotonin (5-HT)2A receptors in affective disorders. Specific binding of [125I]LSD to human platelet pellet sections was saturable, and of high affinity and single. Both ketanserin and spiperone, 5-HT2A selective ligands, inhibited [125I]LSD binding to human platelet pellets with high potency (IC50 values of 0.15 and 0.19 nM, respectively), whereas 5-HT and paroxetine, selective 5- HT re-uptake inhibitors, inhibited binding with a very low potency. These data confirmed that binding sites of human platelet pellets specifically labelled by [125I] LSD were 5-HT2A receptors. The number of 5-HT2A receptors (Bmax of [ 125I] LSD binding) of human platelets obtained from drug-free depressed patients was significantly higher than those of healthy volunteers. There were no statistical differences in the number of 5-HT2A receptors between depressed patients with and without suicidal behaviors. The increased number in platelet 5-HT2A receptotrs may indicate a hyperfunction of the central 5-HT2A receptors. The method with human platelets pellet sections we used is simple and sensitive for investigating platelet 5-HT2A receptors, a diagnostic and therapeutic marker in depressive disorders, in the clinical research. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 43, 号 3-4, p. 48-56, 発行日 1998-12-16 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00048-P00056 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1998, 43(3-4), p.48-56 |