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Autoimmune Cholangitis: Is It an Antimitochondrial Antibody Negative Primary Biliary Cirrhosis?
http://hdl.handle.net/10069/16127
http://hdl.handle.net/10069/16127bf682cc4-6c94-4bc2-b309-65cf1dd06386
名前 / ファイル | ライセンス | アクション |
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acta44_01_02_t.pdf (487.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Autoimmune Cholangitis: Is It an Antimitochondrial Antibody Negative Primary Biliary Cirrhosis? | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune cholangitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | primary biliary cirrhosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune hepatitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antimitochondrial antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antinuclear antibody | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Omagari, Katsuhisa
× Omagari, Katsuhisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Autoimmune cholangitis/cholangiopathy (AIC) is a recently described disease characterized by chronic cholangitis resembling primary biliary cirrhosis (PBC) with a high frequency of antinuclear antibodies (ANA) and with sero-negativity for antimitochondrial antibodies (AMA). Whether AIC is a disease entity distinct from PBC and autoimmune hepatitis (AIH) or whether it is an AMAnegative variant of PBC or a cholangiopathic variant of AIH have so far been controversial. We recently examined the specificities of AMA and ANA in Japanese patients with AIC, PBC and AIH by immunofluorescence, immunoblotting and enzyme inhibition assays using various mitochondrial and nuclear autoantigens including 2-oxoacid dehydrogenase complex, Sp100, gp210, and p62, and found that AIC and PBC had similar patterns of immunoreactivity. However, this duo is of interest because, usually, among sets of autoimmune syndromes, differences in serological targetting are matched by differences in clinical presentation: AIC and PBC seem to be an exception to this rule. While it is true that a single etiological agent can produce a wide range of disease expression, it is possible that seemingly similar clinicopathological features can be induced by pathogenetic mechanisms caused by a diversity of etiological agents. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 44, 号 1-2, p. 11-14, 発行日 1999-06-23 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00011-P00014 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1999, 44(1-2), p.11-14 |