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Rapid Loss of Graft Immunogenicity and Transient Hyporesponsiveness to The Donor Antigen After Rat Liver Transplantation
http://hdl.handle.net/10069/16143
http://hdl.handle.net/10069/16143bca0fbb2-f7fd-45ce-88dc-3e73d2cc0391
名前 / ファイル | ライセンス | アクション |
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acta44_03_04_t.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Rapid Loss of Graft Immunogenicity and Transient Hyporesponsiveness to The Donor Antigen After Rat Liver Transplantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antigen presenting cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acute rejection response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | graft immunogenicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cells response | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Gu, Weili
× Gu, Weili× Yamaguchi, Junzo× Hashimoto, Toshiaki× Yamamoto, Takao× Nakayama, Eiichi× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In orthotopic liver transplantation from Lewis (LEW) into Wistar Furth (WF) rats, a transient acute rejection response is usually followed by spontaneous tolerance of the graft. In this study, we investigated the alloimmunostimulatory ability of the graft and recipient spleen after liver transplantation, and studied the kinetic response of the recipient to the donor antigen. Alloimmunogenicity of the liver graft and recipient spleen, and kinetic response of the recipient were investigated in in vivo system. Alloimmunostimulatory ability of the liver graft disappeared by day 3 after transplantation. Alloimmunostimulatory capacity of recipient spleen was maximum 12 hours after grafting and rapidly disappeared thereafter. Challenge with normal LEW lymphocytes into recipient WF rats at 14, 28, 56 days after liver transplantation induced a progressive increase in rejection response. Our results suggest that rapid loss of graft immunogenicity and transient hyporesponsiveness to the donor antigen occur after grafting in our model. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 44, 号 3-4, p. 31-38, 発行日 1999-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00031-P00038 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1999, 44(3-4), p.31-38 |