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Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis
http://hdl.handle.net/10069/16154
http://hdl.handle.net/10069/16154af373e61-342d-4451-97ff-0abf48bbb500
名前 / ファイル | ライセンス | アクション |
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acta45_01_04_t.pdf (1.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Low-Dose and Long-Term 14-Member Macrolide Therapy for Palomoplantar Pustulosis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | palmoplantar pustulosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrolide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | keratinocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-8 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Matsunaga, Yoshitaka
× Matsunaga, Yoshitaka× Bae, Sangjae× Akikawa, Tomio× Kadota, Jun-Ichi× Katayama, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the clinical efficacy of low-dose and long-term 14-member macrolide therapy for 33 patients with Palomoplantar Pustulosis (PPP) most of whom showed a poor clinical response to topical corticosteroid and/or photo chemotherapy. After 4-12 weeks treatment with oral erythromycin (EM; 600mg/day) or clarithromycin (CAM ; 200 mg/day) in combination with previously used corticosteroid ointment, clinical evaluation was made on the basis of clinical score. Results are as follows: marked improvement ; 19 patients (57.6%), moderate improvement ; 7 patients, no clinical response ; 7 patients. There was no serious side effect during the observation period. In vitro studies suggest that CAM, a 14-member macrolide, significantly down-regulated IL-8 production by keratinocytes stimulated with combination of IFNホウ and TNFホア or staphylococcal-superantigen(SEB)and IFNホウ both at protein and mRNA levels. We would like to propose that low-dose and long-term 14-member macrolide therapy is effective and an alternate therapy for PPP with poor response to ordinal dermatological therapy of which mechanism is presumable inhibition of neutrophil chemotaxisis by inhibiting IL-8 production by keratinocytes. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 45, 号 1-2, p. 25-31, 発行日 2000-06-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00025-P00031 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2000, 45(1-2), p.25-31 |