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Prognostic Value of Circulating CA 19-9 in Colorectal Cancer Patients
http://hdl.handle.net/10069/16158
http://hdl.handle.net/10069/16158f6d965dd-bcf5-4f6b-9a2d-3c40dd4a5e56
名前 / ファイル | ライセンス | アクション |
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acta45_01_08_t.pdf (499.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Prognostic Value of Circulating CA 19-9 in Colorectal Cancer Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CA19-9 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sialyl Lea | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CEA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prognostic factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakagoe, Tohru
× Nakagoe, Tohru× Sawai, Terumitsu× Tsuji, Takashi× Jibiki, Masaaki× Ohbatake, Masayuki× Nakashima, Atsushi× Yamaguchi, Hiroyuki× Kurosaki, Nobuko× Yasutake, Toru× Ayabe, Hiroyoshi× Miyashita, Hiroko× Arisawa, Kokichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aims: We examined the preoperative serum levels of sialyl Lewisa (CA19-9) and carcinoembryonic antigen (CEA) in 262 colorectal cancer patients, in order to clarify whether or not the prognostic value of CA19-9 after curative surgery is superior to that of CEA. Patients and Methods: The patients were divided into two groups: low or high antigen groups (higher or lower than a selected diagnostic-based cut-off value). For evaluation of the prognostic value of CA19-9 and CEA, the disease-free interval was studied. Results: The disease-free interval of patients with a high serum levels of CA19-9 or CEA was significantly shorter than for those patients with a low serum level of the particular antigen (P<0.0001 and P=0.0009, respectively). The disease-free interval of patients with stage I/II tumors who had a high CA19-9 level was significantly shorter than in those patients with stage I/II tumors with low CA19-9 levels (P=0.0020). In contrast, the disease-free interval of patients with stage I/II tumors who had a low or high CEA level did not differ. Cox s regression analysis revealed that a high serum level of CA19-9 or CEA was an independent predictor for short disease-free interval after curative surgery, separate from stage (Hazard ratio=2.65 or 1.68, respectively, versus a low serum level of each respective antigen) . Conclusions: These data suggest that the preoperative serum level of CA19-9 was a stronger prognostic factor after curative surgery than CEA. Furthermore, in contrast to CEA, CA19-9 provides more prognostic information than that obtained by conventional staging methods in patients with stage I/II tumors. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 45, 号 1-2, p. 47-50, 発行日 2000-06-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00047-P00050 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2000, 45(1-2), p.47-50 |