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Review Article Aberration in Signal Transduction Pathway in Human T-Cell Leukemia Virus Type I-Infected T Cells
http://hdl.handle.net/10069/16163
http://hdl.handle.net/10069/1616366e9080f-ad5b-4276-9db5-14838c7174de
名前 / ファイル | ライセンス | アクション |
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acta45_03_01_t.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Review Article Aberration in Signal Transduction Pathway in Human T-Cell Leukemia Virus Type I-Infected T Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ATL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HTLV-I | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tax | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NF-KB/Rel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AP-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Jak/STAT | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Mori, Naoki
× Mori, Naoki× Fujii, Masahiro× Yamamoto, Naoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Adult T-cell leukemia (ATL) is a fatal T-lymphoproliferative disorder, and its development is associated with infection by human T-cell leukemia virus type I (HTLV-I). The molecular mechanism of leukemogenesis has not yet been elucidated. However, several studies have suggested that aberrations in signal transduction in virus-infected T cells are involved in the development of the disease. For instance, NF-ホコB/Rel, AP-1, and Jak/STAT signaling pathways are transiently activated in normal T cells by growth-signals, whereas they are constitutively deployed in HTLV-I-infected T-cell lines. The HTLV-I viral transactivator Tax has oncogenic properties, and is a key molecule in ATL development. Tax activates several transcription factors, including NF-ホコB/Rel and AP-1 in HTLV-I-transformed T-cell lines, and induces the expression of STAT proteins. Unlike HTLV-I-transformed T-cell lines, primary ATL cells express low levels of Tax protein. Nevertheless, the NF-ホコB/Rel, AP-1, and Jak/STAT signaling pathways in primary ATL cells are also constitutively activated. Thus, the aberration in signal transduction pathway may be a common key factor to prolonged survival and proliferation of HTLV-Iinfected T cells in vitro and in vivo, but the mechanisms seem to be different. Aberration in signal transduction could be targeted for the therapeutic control of HTLV-I-associated disease. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 45, 号 3-4, p. 1-8, 発行日 2000-12-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00001-P00008 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2000, 45(3-4), p.1-8 |