WEKO3
アイテム
{"_buckets": {"deposit": "44814bad-2d3f-465d-8ec4-c86a3390afa2"}, "_deposit": {"created_by": 2, "id": "20219", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "20219"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00020219", "sets": ["1398"]}, "author_link": ["85438", "85441", "85443", "85439", "85444", "85445", "85440", "85442", "85446", "85448", "85447"], "item_3_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-12-20", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "19", "bibliographicPageStart": "15", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Acta medica Nagasakiensia"}]}]}, "item_3_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The Interferon (IFN) receptor-mediated signal transduction pathways involve the two novel DNA-binding factors, interferon regulatory factor-1 (IRF-1) and IRF-2. Both recognize the same DNA sequence, in which the expression ratio of IRF-1 to IRF-2 is relevant to induction of IFN-inducible genes, because IRF-1 acts as a transcriptional activator and IRF-2 as a counterpart. In the present study, 54 patients with chronic hepatitis C and the age-and sex-matched 7 subjects with fatty liver as a control were subjected to analysis of the expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue obtained at the time of livert biopsy by reverse transcription-polymerase chain reaction in combination with a restriction fragment length polymorphism assay. The expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue in patients chronically infected by hepatitis C virus (HCV) was significantly higher than that in control, although the values did not correlate with the serum levels of HCV-RNA. Of 54 patients, 28 received IFN treatment, resulting in complete response in 8 patients. With respect to responsiveness to IFN treatment, patients who had complete response had the relatively lower ratios of IRF-1 to IRF-2 mRNA in the liver tissue, compared with those who did not. These results indicate that the IFN-mediated pathway is spontaneously activated in patients with chronic hepatitis C, and that its preceded overactivation counteracts on the efficacy of IFN treatment in these patients.", "subitem_description_type": "Abstract"}]}, "item_3_description_64": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Acta medica Nagasakiensia. 2000, 45(3-4), p.15-19", "subitem_description_type": "Other"}]}, "item_3_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508430", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00016055", "subitem_source_identifier_type": "ISSN"}]}, "item_3_text_62": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "P00015-P00019"}]}, "item_3_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "85438", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakao, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "85439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morikawa, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "85440", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inokuchi, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "85441", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hamasaki, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "85442", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuruta, Shotaro"}], "nameIdentifiers": [{"nameIdentifier": "85443", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "85444", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yatsuhashi, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "85445", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kusumoto, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "85446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishii, Nobuko"}], "nameIdentifiers": [{"nameIdentifier": "85447", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eguchi, Katsumi"}], "nameIdentifiers": [{"nameIdentifier": "85448", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "acta45_03_03_t.pdf", "filesize": [{"value": "557.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 557500.0, "url": {"label": "acta45_03_03_t.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/20219/files/acta45_03_03_t.pdf"}, "version_id": "a9c96db7-f3ae-4592-b736-fdeed343c445"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "interferon treatment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chronic hepatitis C", "subitem_subject_scheme": "Other"}, {"subitem_subject": "inter feron regulatory factor-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interferon regulatory factor-2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hepatitis C virus", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus"}]}, "item_type_id": "3", "owner": "2", "path": ["1398"], "permalink_uri": "http://hdl.handle.net/10069/16165", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-03-13"}, "publish_date": "2008-03-13", "publish_status": "0", "recid": "20219", "relation": {}, "relation_version_is_last": true, "title": ["Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus"], "weko_shared_id": -1}
Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus
http://hdl.handle.net/10069/16165
http://hdl.handle.net/10069/16165c0980983-e176-4d0a-afe1-505877499300
名前 / ファイル | ライセンス | アクション |
---|---|---|
acta45_03_03_t.pdf (557.5 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Attenuation of Responsiveness to Interferon-α Treatment by Preceded Overactivation of Interferon-mediated Pathway in Patients Chronically Infected by Hepatitis C Virus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon treatment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic hepatitis C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inter feron regulatory factor-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon regulatory factor-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hepatitis C virus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakata, Keisuke
× Nakata, Keisuke× Nakao, Kazuhiko× Morikawa, Takashi× Inokuchi, Kaoru× Hamasaki, Keisuke× Tsuruta, Shotaro× Kato, Yuji× Yatsuhashi, Hiroshi× Kusumoto, Yukio× Ishii, Nobuko× Eguchi, Katsumi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Interferon (IFN) receptor-mediated signal transduction pathways involve the two novel DNA-binding factors, interferon regulatory factor-1 (IRF-1) and IRF-2. Both recognize the same DNA sequence, in which the expression ratio of IRF-1 to IRF-2 is relevant to induction of IFN-inducible genes, because IRF-1 acts as a transcriptional activator and IRF-2 as a counterpart. In the present study, 54 patients with chronic hepatitis C and the age-and sex-matched 7 subjects with fatty liver as a control were subjected to analysis of the expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue obtained at the time of livert biopsy by reverse transcription-polymerase chain reaction in combination with a restriction fragment length polymorphism assay. The expression ratio of IRF-1 to IRF-2 mRNA in the liver tissue in patients chronically infected by hepatitis C virus (HCV) was significantly higher than that in control, although the values did not correlate with the serum levels of HCV-RNA. Of 54 patients, 28 received IFN treatment, resulting in complete response in 8 patients. With respect to responsiveness to IFN treatment, patients who had complete response had the relatively lower ratios of IRF-1 to IRF-2 mRNA in the liver tissue, compared with those who did not. These results indicate that the IFN-mediated pathway is spontaneously activated in patients with chronic hepatitis C, and that its preceded overactivation counteracts on the efficacy of IFN treatment in these patients. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 45, 号 3-4, p. 15-19, 発行日 2000-12-20 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00015-P00019 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2000, 45(3-4), p.15-19 |