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Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction
http://hdl.handle.net/10069/16176
http://hdl.handle.net/10069/161767381a3e6-552f-4c2b-b744-9ef559ecda70
名前 / ファイル | ライセンス | アクション |
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acta46_01_04_t.pdf (6.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CA19-9 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hydronephrosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Li, Shengwen
× Li, Shengwen× Nomata, Koichiro× Hayashi, Tomayoshi× Aoki, Daiyu× Kanda, Shigeru× Kanetake, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | High serum levels of carbohydrate antigen19-9 (CA19-9) have been detected in patients with pancreatic cancer and described in several recent case reports of patients with hydronephrosis. However, the mechanism of high serum levels of CA19-9 among hydronephrosis cases remains to be elucidated. In this study, we established a mouse unilateral ureteral obstruction (UUO) model to investigate the expression of CA19-9 protein in renal tissue. To investigate the progression of hydronephrosis following UUO, MR urography and pathological analysis were performed. CA19-9 expression was examined by immunohistochemistry and western blot analysis. MR urography revealed that the grade of pelvic dilatation increased in a time dependent manner. Pathologically, both interstitial cellular infiltration and fibrosis were detected from the second to the fourteenth day after surgery in UUO mice. CA19-9 was detected in the UUO kidney after the second day. The immunoblot analysis revealed that the elevated expression of CA19-9 was demonstrated at an early stage of obstructive nephropathy. Our study shows that the ureteral obstructed kidney is dominated by cell infiltration and induced fibrosis. The selective expression of CA19-9 was detected in renal fibrous tissue. Based on these findings, the level of CA19-9 might be a good indicator for onset of renal fibrosis induced by obstruction. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 46, 号 1-2, p. 21-25, 発行日 2001-06-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00021-P00025 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2001, 46(1-2), p.21-25 |