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Prolonged Radiation Damage in Rat Colon and Urokinase Expression in Epithelium
http://hdl.handle.net/10069/16192
http://hdl.handle.net/10069/16192c14d2660-9b41-4451-af1d-a888fea8a96e
名前 / ファイル | ライセンス | アクション |
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acta46_03_08_t.pdf (983.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Prolonged Radiation Damage in Rat Colon and Urokinase Expression in Epithelium | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation induced enterocolitis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epithelial reproduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | uPA | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Hayashida, Masayuki
× Hayashida, Masayuki× Shichijo, Kazuko× Matsuu, Mutsumi× Minami, Kazunori× Okimoto, Tomoaki× Nakayama, Toshiyuki× Sekine, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although radiation therapy plays important role in the treatment of gynecological tumors, it may cause radiation injury as a late effect. Several recent reports show that urokinase such as urokinase type plasminogen activator (uPA) contributes to the repair of ulcerative lesions of the colon epithelium. We studied radiation induced enterocolitis using rat animal models. Seventy-two female Wistar rats were irradiated by a single fraction dose of 36Gy at laparotomy. Histological changes and activity of urokinase system were investigated after irradiation. Ulcers were observed in irradiated field in 12 of 19 animals (63%) even at 60th week after irradiation. Urokinase expressions were observed in the margins of active ulcer. Urokinase was thought to play important role in exacerbation of ulcer formation. Expression of uPA was also observed in submucosal glands. Ischaemic changes were not observed in irradiated colon despite sclerosing vasculitis. It is suggested that uPA played reciprocal roles in radiation induced enterocolitis: healing and aggravation of ulcer. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 46, 号 3-4, p. 39-45, 発行日 2001-12-19 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00039-P00045 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2001, 46(3-4), p.39-45 |